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• W2091041547 abstract "Protein C is a vitamin K-dependent regulator of blood coagulation. Activated protein C is regulated in plasma in large part by two inhibitors, protein C inhibitor and α1-antitrypsin. Complexes of activated protein C with both inhibitors in plasma samples from subjects with normal or pathologic pregnancy were measured. In normal pregnancy we observed a progressive and significant increase in activated protein C/α1-antitrypsin complex levels, from 9 ± 3 ng/ml in the first trimester to 16 ± 3 ng/ml in the third trimester, as well as an increase in α1-antitrypsin plasma levels. In severe preeclampsia, but not in chronic hypertension with superimposed severe preeclampsia, there was a greater increase in activated protein C/α1-antitrypsin levels (25 ± 10 ng/ml) (p < 0.001) and a decrease in protein C and protein C inhibitor levels as compared with normal pregnant women at similar gestational ages. These data show an increase in the activation of the protein C pathway in both normal and pathologic pregnancy and provide evidence for an enhancement of thrombin generation in severe preeclampsia compared with chronic hypertension with superimposed severe preeclampsia. Protein C is a vitamin K-dependent regulator of blood coagulation. Activated protein C is regulated in plasma in large part by two inhibitors, protein C inhibitor and α1-antitrypsin. Complexes of activated protein C with both inhibitors in plasma samples from subjects with normal or pathologic pregnancy were measured. In normal pregnancy we observed a progressive and significant increase in activated protein C/α1-antitrypsin complex levels, from 9 ± 3 ng/ml in the first trimester to 16 ± 3 ng/ml in the third trimester, as well as an increase in α1-antitrypsin plasma levels. In severe preeclampsia, but not in chronic hypertension with superimposed severe preeclampsia, there was a greater increase in activated protein C/α1-antitrypsin levels (25 ± 10 ng/ml) (p < 0.001) and a decrease in protein C and protein C inhibitor levels as compared with normal pregnant women at similar gestational ages. These data show an increase in the activation of the protein C pathway in both normal and pathologic pregnancy and provide evidence for an enhancement of thrombin generation in severe preeclampsia compared with chronic hypertension with superimposed severe preeclampsia." @default.
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• W2091041547 date "1991-05-01" @default.
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• W2091041547 title "Complexes of activated protein C with α1-antitrypsin in normal pregnancy and in severe preeclampsia" @default.
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• W2091041547 doi "https://doi.org/10.1016/0002-9378(91)90706-w" @default.
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