FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091041569> ?p ?o ?g. }

• W2091041569 endingPage "554a" @default.
• W2091041569 startingPage "554a" @default.
• W2091041569 abstract "Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder. Familial AD (FAD) mutations in presenilins have been linked to Ca2+ signaling abnormalities. Presenilins (PS) are 50 kDa proteins in the endoplasmic reticulum (ER) membrane. The cleaved presenilins are well known as catalytic components of a gamma-secretase, which cleaves the amyloid precursor protein (APP) and releases the amyloid beta-peptide. In addition uncleaved presenilins function as passive ER Ca2+ leak channels which control steady-state ER Ca2+ levels. It was found that many FAD mutations in presenilins result in loss of ER Ca2+ leak function, leading to ER Ca2+ overload and supranormal Ca2+ release from the ER. The ER Ca2+ leak function of presenilins is independent of their gamma-secretase activity. We suggested that presenilins affect store-operated calcium influx (SOC) by controlling the filling state of ER Ca2+ stores. To determinate the influence of FAD presenilins mutations on SOC we performed a series of patch-clamp experiments in whole-cell mode.PS1-M146V and PS1-ΔE9 mutants have been shown to have loss and gain of ER Ca2+ leak channel function respectively. A decrease in maximum amplitude and speed of SOC current activation was observed in SK-N-SH neuroblastoma cells and primary culture of rat hippocampal neurons transfected with PS1-M146V mutant comparing to wild type PS1 transfected cells. An increase in maximum amplitude and speed of SOC current activation was observed in cells transfected by PS1-ΔE9 mutant comparing to wild type PS1. In experiments with triple transgenic AD mice hippocampal neurons (3XTg mice; KI-PS1M146V, Thy1-APPKM670/671NL, Thy1-tauP301L) the maximum amplitude of SOC were decreased comparing to WT, but the speed of activation was the same for 3XTg and WT hippocampal neurons. Electrophysiological properties of all impaired SOCs suggest that TRPC1 is the main target of presenilins FAD mutations affect." @default.
• W2091041569 created "2016-06-24" @default.
• W2091041569 creator A5021417865 @default.
• W2091041569 creator A5074668880 @default.
• W2091041569 creator A5079954066 @default.
• W2091041569 creator A5085587807 @default.
• W2091041569 creator A5087845947 @default.
• W2091041569 date "2011-02-01" @default.
• W2091041569 modified "2023-10-17" @default.
• W2091041569 title "Familial Alzheimer's Disease Mutations in Presenilin-1 and Store-Operated Calcium Entry" @default.
• W2091041569 doi "https://doi.org/10.1016/j.bpj.2010.12.3222" @default.
• W2091041569 hasPublicationYear "2011" @default.
• W2091041569 type Work @default.
• W2091041569 sameAs 2091041569 @default.
• W2091041569 citedByCount "0" @default.
• W2091041569 crossrefType "journal-article" @default.
• W2091041569 hasAuthorship W2091041569A5021417865 @default.
• W2091041569 hasAuthorship W2091041569A5074668880 @default.
• W2091041569 hasAuthorship W2091041569A5079954066 @default.
• W2091041569 hasAuthorship W2091041569A5085587807 @default.
• W2091041569 hasAuthorship W2091041569A5087845947 @default.
• W2091041569 hasConcept C126322002 @default.
• W2091041569 hasConcept C169760540 @default.
• W2091041569 hasConcept C175344181 @default.
• W2091041569 hasConcept C2779134260 @default.
• W2091041569 hasConcept C502032728 @default.
• W2091041569 hasConcept C519063684 @default.
• W2091041569 hasConcept C71924100 @default.
• W2091041569 hasConcept C86803240 @default.
• W2091041569 hasConceptScore W2091041569C126322002 @default.
• W2091041569 hasConceptScore W2091041569C169760540 @default.
• W2091041569 hasConceptScore W2091041569C175344181 @default.
• W2091041569 hasConceptScore W2091041569C2779134260 @default.
• W2091041569 hasConceptScore W2091041569C502032728 @default.
• W2091041569 hasConceptScore W2091041569C519063684 @default.
• W2091041569 hasConceptScore W2091041569C71924100 @default.
• W2091041569 hasConceptScore W2091041569C86803240 @default.
• W2091041569 hasIssue "3" @default.
• W2091041569 hasLocation W20910415691 @default.
• W2091041569 hasOpenAccess W2091041569 @default.
• W2091041569 hasPrimaryLocation W20910415691 @default.
• W2091041569 hasRelatedWork W2004405029 @default.
• W2091041569 hasRelatedWork W2087011206 @default.
• W2091041569 hasRelatedWork W2094357331 @default.
• W2091041569 hasRelatedWork W2098977708 @default.
• W2091041569 hasRelatedWork W2313342767 @default.
• W2091041569 hasRelatedWork W2463836545 @default.
• W2091041569 hasRelatedWork W2514357924 @default.
• W2091041569 hasRelatedWork W2986755863 @default.
• W2091041569 hasRelatedWork W4211156109 @default.
• W2091041569 hasRelatedWork W4211233037 @default.
• W2091041569 hasVolume "100" @default.
• W2091041569 isParatext "false" @default.
• W2091041569 isRetracted "false" @default.
• W2091041569 magId "2091041569" @default.
• W2091041569 workType "article" @default.