FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091041722> ?p ?o ?g. }

• W2091041722 endingPage "142" @default.
• W2091041722 startingPage "129" @default.
• W2091041722 abstract "The parenteral administration of antivenoms is the cornerstone of snakebite envenoming therapy. Efforts are made to ensure that antivenoms of adequate efficacy and safety are available world-wide. We address the main issues to be considered for the development and manufacture of improved antivenoms. Those include: (a) A knowledge-based composition design of venom mixtures used for immunization, based on biochemical, immunological, toxicological, taxonomic, clinical and epidemiological data; (b) a careful selection and adequate management of animals used for immunization; (c) well-designed immunization protocols; (d) sound innovations in plasma fractionation protocols to improve recovery, tolerability and stability of antivenoms; (e) the use of recombinant toxins as immunogens to generate antivenoms and the synthesis of engineered antibodies to substitute for animal-derived antivenoms; (f) scientific studies of the contribution of existing manufacturing steps to the inactivation or removal of viruses and other zoonotic pathogens; (g) the introduction of novel quality control tests; (h) the development of in vitro assays in substitution of in vivo tests to assess antivenom potency; and (i) scientifically-sound pre-clinical and clinical assessments of antivenoms. These tasks demand cooperative efforts at all main stages of antivenom development and production, and need concerted international partnerships between key stakeholders." @default.
• W2091041722 created "2016-06-24" @default.
• W2091041722 creator A5006405586 @default.
• W2091041722 creator A5063475199 @default.
• W2091041722 creator A5079027751 @default.
• W2091041722 date "2011-05-01" @default.
• W2091041722 modified "2023-10-16" @default.
• W2091041722 title "Antivenoms for the treatment of snakebite envenomings: The road ahead" @default.
• W2091041722 cites W1898668025 @default.
• W2091041722 cites W1920136132 @default.
• W2091041722 cites W1969265645 @default.
• W2091041722 cites W1969723716 @default.
• W2091041722 cites W1969815685 @default.
• W2091041722 cites W1970723340 @default.
• W2091041722 cites W1970927146 @default.
• W2091041722 cites W1971147824 @default.
• W2091041722 cites W1971727851 @default.
• W2091041722 cites W1971852751 @default.
• W2091041722 cites W1972036809 @default.
• W2091041722 cites W1974677556 @default.
• W2091041722 cites W1974930003 @default.
• W2091041722 cites W1975925461 @default.
• W2091041722 cites W1976745046 @default.
• W2091041722 cites W1978986477 @default.
• W2091041722 cites W1979000314 @default.
• W2091041722 cites W1979103616 @default.
• W2091041722 cites W1980206863 @default.
• W2091041722 cites W1980253473 @default.
• W2091041722 cites W1980655108 @default.
• W2091041722 cites W1980719058 @default.
• W2091041722 cites W1988063313 @default.
• W2091041722 cites W1988946293 @default.
• W2091041722 cites W1991411892 @default.
• W2091041722 cites W1991669097 @default.
• W2091041722 cites W1992240357 @default.
• W2091041722 cites W1992333130 @default.
• W2091041722 cites W1993558161 @default.
• W2091041722 cites W1995292169 @default.
• W2091041722 cites W1995584202 @default.
• W2091041722 cites W1998542746 @default.
• W2091041722 cites W2000518549 @default.
• W2091041722 cites W2003557975 @default.
• W2091041722 cites W2007504861 @default.
• W2091041722 cites W2007955614 @default.
• W2091041722 cites W2008964357 @default.
• W2091041722 cites W2010169198 @default.
• W2091041722 cites W2010422388 @default.
• W2091041722 cites W2011746102 @default.
• W2091041722 cites W2012598789 @default.
• W2091041722 cites W2013622729 @default.
• W2091041722 cites W2014187932 @default.
• W2091041722 cites W2014338824 @default.
• W2091041722 cites W2014928855 @default.
• W2091041722 cites W2014974853 @default.
• W2091041722 cites W2015718953 @default.
• W2091041722 cites W2015748866 @default.
• W2091041722 cites W2017038754 @default.
• W2091041722 cites W2019553456 @default.
• W2091041722 cites W2020356184 @default.
• W2091041722 cites W2020533801 @default.
• W2091041722 cites W2021425861 @default.
• W2091041722 cites W2022893764 @default.
• W2091041722 cites W2024630021 @default.
• W2091041722 cites W2024931154 @default.
• W2091041722 cites W2027259074 @default.
• W2091041722 cites W2027344849 @default.
• W2091041722 cites W2028285527 @default.
• W2091041722 cites W2028739778 @default.
• W2091041722 cites W2030899382 @default.
• W2091041722 cites W2032009841 @default.
• W2091041722 cites W2032588094 @default.
• W2091041722 cites W2032628392 @default.
• W2091041722 cites W2032798153 @default.
• W2091041722 cites W2034656225 @default.
• W2091041722 cites W2036181958 @default.
• W2091041722 cites W2036662487 @default.
• W2091041722 cites W2037439512 @default.
• W2091041722 cites W2039300242 @default.
• W2091041722 cites W2039356106 @default.
• W2091041722 cites W2042793563 @default.
• W2091041722 cites W2043381167 @default.
• W2091041722 cites W2043819351 @default.
• W2091041722 cites W2045213075 @default.
• W2091041722 cites W2047348578 @default.
• W2091041722 cites W2048849328 @default.
• W2091041722 cites W2049569956 @default.
• W2091041722 cites W2051350778 @default.
• W2091041722 cites W2051583331 @default.
• W2091041722 cites W2051724757 @default.
• W2091041722 cites W2053031581 @default.
• W2091041722 cites W2053565382 @default.
• W2091041722 cites W2056256914 @default.
• W2091041722 cites W2056283650 @default.
• W2091041722 cites W2057097125 @default.
• W2091041722 cites W2059564760 @default.
• W2091041722 cites W2060721195 @default.
• W2091041722 cites W2062420086 @default.
• W2091041722 cites W2063293679 @default.

• next