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- W2091042488 abstract "Introduction miR biogenesis miR and Cancer miR and Apoptosis Conclusion Abstract MicroRNAs (miRs) are small non‐coding RNAs regulating gene expression at the post‐transcriptional and/or translational levels. miRs play important roles in diverse biological processes, including development, cell differentiation, proliferation and apoptosis. Recent evidence has shown that miR loci frequently map to cancer‐associated genomic regions and deregulated miR expression profiles are associated with many cancer types, implicating miRs in crucial processes that lead to tumourigenesis. Here, we review the current findings about miRs and tumourigenesis, focusing on their involvement in the apoptosis pathway. A significant observation is that greater than one‐quarter of all known human miRs were reported to be deregulated in at least one cancer type. The expression of a subset of miRs ( e.g. miR‐21 and miR‐155) was found to be consistently up‐regulated, whereas another subset of miRs (e.g.miR‐143 and miR‐145) was consistently down‐regulated across different cancer types suggesting their involvement in regulating common cellular processes whose deregulation may lead to tumourigenesis. Several miRs were implicated to play roles in cell proliferation and apoptosis. Some miRs, such as miR‐29b and miR‐15–16, influence only the apoptotic pathway, whereas others including let‐7/miR‐98 and miR‐17–92 may play roles in both the apoptotic and cell‐proliferation pathways. In conclusion, although our current understanding of the functions of miRs is still fragmentary, taken together, this review highlights the complex and intricate roles that miRs play in the regulation of cellular processes. Perturbation of the expression of miRs may thus lead to tumourigenesis." @default.
- W2091042488 created "2016-06-24" @default.
- W2091042488 creator A5068017110 @default.
- W2091042488 creator A5089791856 @default.
- W2091042488 date "2009-01-01" @default.
- W2091042488 modified "2023-10-18" @default.
- W2091042488 title "MicroRNA and cancer - focus on apoptosis" @default.
- W2091042488 cites W144423133 @default.
- W2091042488 cites W1585481509 @default.
- W2091042488 cites W1920303762 @default.
- W2091042488 cites W1958284284 @default.
- W2091042488 cites W1963691340 @default.
- W2091042488 cites W1965306643 @default.
- W2091042488 cites W1966116761 @default.
- W2091042488 cites W1967705046 @default.
- W2091042488 cites W1969015715 @default.
- W2091042488 cites W1970829776 @default.
- W2091042488 cites W1972755526 @default.
- W2091042488 cites W1972892962 @default.
- W2091042488 cites W1975308625 @default.
- W2091042488 cites W1976324983 @default.
- W2091042488 cites W1979159960 @default.
- W2091042488 cites W1979268646 @default.
- W2091042488 cites W1979490110 @default.
- W2091042488 cites W1983371018 @default.
- W2091042488 cites W1985402095 @default.
- W2091042488 cites W1985563073 @default.
- W2091042488 cites W1988376520 @default.
- W2091042488 cites W1989653928 @default.
- W2091042488 cites W1992710380 @default.
- W2091042488 cites W2000093333 @default.
- W2091042488 cites W2004067791 @default.
- W2091042488 cites W2005006705 @default.
- W2091042488 cites W2006797972 @default.
- W2091042488 cites W2008955962 @default.
- W2091042488 cites W2014064723 @default.
- W2091042488 cites W2015018301 @default.
- W2091042488 cites W2015858554 @default.
- W2091042488 cites W2020080445 @default.
- W2091042488 cites W2024704386 @default.
- W2091042488 cites W2026581189 @default.
- W2091042488 cites W2027097496 @default.
- W2091042488 cites W2027873015 @default.
- W2091042488 cites W2032235087 @default.
- W2091042488 cites W2035213975 @default.
- W2091042488 cites W2036169252 @default.
- W2091042488 cites W2036534625 @default.
- W2091042488 cites W2037631027 @default.
- W2091042488 cites W2042027879 @default.
- W2091042488 cites W2042504292 @default.
- W2091042488 cites W2045402423 @default.
- W2091042488 cites W2047213909 @default.
- W2091042488 cites W2050465838 @default.
- W2091042488 cites W2050869737 @default.
- W2091042488 cites W2051227958 @default.
- W2091042488 cites W2051960497 @default.
- W2091042488 cites W2054067310 @default.
- W2091042488 cites W2054109341 @default.
- W2091042488 cites W2058158664 @default.
- W2091042488 cites W2062290101 @default.
- W2091042488 cites W2066636886 @default.
- W2091042488 cites W2067617459 @default.
- W2091042488 cites W2070571588 @default.
- W2091042488 cites W2071142564 @default.
- W2091042488 cites W2071596792 @default.
- W2091042488 cites W2072886988 @default.
- W2091042488 cites W2074629894 @default.
- W2091042488 cites W2074664629 @default.
- W2091042488 cites W2075258024 @default.
- W2091042488 cites W2076100820 @default.
- W2091042488 cites W2076287538 @default.
- W2091042488 cites W2080041996 @default.
- W2091042488 cites W2083381199 @default.
- W2091042488 cites W2085592081 @default.
- W2091042488 cites W2090017296 @default.
- W2091042488 cites W2091651379 @default.
- W2091042488 cites W2094340038 @default.
- W2091042488 cites W2095671229 @default.
- W2091042488 cites W2099099087 @default.
- W2091042488 cites W2099517697 @default.
- W2091042488 cites W2100159558 @default.
- W2091042488 cites W2100975741 @default.
- W2091042488 cites W2101543035 @default.
- W2091042488 cites W2103211592 @default.
- W2091042488 cites W2104610341 @default.
- W2091042488 cites W2106638896 @default.
- W2091042488 cites W2107515690 @default.
- W2091042488 cites W2109567968 @default.
- W2091042488 cites W2110666579 @default.
- W2091042488 cites W2112192177 @default.
- W2091042488 cites W2113047680 @default.
- W2091042488 cites W2113707167 @default.
- W2091042488 cites W2116000203 @default.
- W2091042488 cites W2119066197 @default.
- W2091042488 cites W2121629705 @default.
- W2091042488 cites W2123168045 @default.
- W2091042488 cites W2124086076 @default.
- W2091042488 cites W2125536613 @default.