Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091052570> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2091052570 endingPage "531a" @default.
- W2091052570 startingPage "531a" @default.
- W2091052570 abstract "Elucidating the structure of Aβ40/Aβ42 fibrils is of interest in Alzheimer's disease research because it is required for designing therapeutics that target fibril formation at an early stage of the disease. Based on the cryoEM measurements and on ssNMR data, we probe various amyloid fibril organizations. Our study demonstrates that the two-fold symmetry tubular Aβ42 fibril model with the C-termini facing the external surface of the fibril has a cavity, while model with the C-termini facing the internal surface of the fibril shrinks the tubular cavity. Experimentally, data for the three-fold symmetry structure of the Aβ9-40 fibril suggest formation of tight hydrophobic core through M35 interactions across the fibril axis and strong I31-V39 interactions between different cross-β units. Herein, based on ssNMR data, we probe various models with three-fold symmetry of the full-length Aβ40. We revealed that the unique Aβ40 triangular structure has a large cavity along the fibril axis. Finally, the N-termini in Aβ40/Aβ42 fibrils can assist in the stabilization of the fibrilby interacting with the U-turn domains or with the C-termini domains. Our findings point to the relevance of the cavity in oligomers which should be considered, when targeting oligomer toxicity. This project has been funded in whole or in part with Federal funds from the NCI, NIH, under contract number HHSN261200800001E." @default.
- W2091052570 created "2016-06-24" @default.
- W2091052570 creator A5025357844 @default.
- W2091052570 creator A5027274925 @default.
- W2091052570 creator A5076498226 @default.
- W2091052570 date "2011-02-01" @default.
- W2091052570 modified "2023-09-26" @default.
- W2091052570 title "Alzheimer Aβ Amyloid Annular Fibrils: Insight Into Polymorphism" @default.
- W2091052570 doi "https://doi.org/10.1016/j.bpj.2010.12.3100" @default.
- W2091052570 hasPublicationYear "2011" @default.
- W2091052570 type Work @default.
- W2091052570 sameAs 2091052570 @default.
- W2091052570 citedByCount "4" @default.
- W2091052570 countsByYear W20910525702015 @default.
- W2091052570 countsByYear W20910525702019 @default.
- W2091052570 countsByYear W20910525702021 @default.
- W2091052570 crossrefType "journal-article" @default.
- W2091052570 hasAuthorship W2091052570A5025357844 @default.
- W2091052570 hasAuthorship W2091052570A5027274925 @default.
- W2091052570 hasAuthorship W2091052570A5076498226 @default.
- W2091052570 hasBestOaLocation W20910525701 @default.
- W2091052570 hasConcept C12554922 @default.
- W2091052570 hasConcept C142724271 @default.
- W2091052570 hasConcept C178790620 @default.
- W2091052570 hasConcept C185592680 @default.
- W2091052570 hasConcept C27523624 @default.
- W2091052570 hasConcept C2779134260 @default.
- W2091052570 hasConcept C2780642029 @default.
- W2091052570 hasConcept C2994168385 @default.
- W2091052570 hasConcept C3019447875 @default.
- W2091052570 hasConcept C71924100 @default.
- W2091052570 hasConcept C8010536 @default.
- W2091052570 hasConcept C86803240 @default.
- W2091052570 hasConceptScore W2091052570C12554922 @default.
- W2091052570 hasConceptScore W2091052570C142724271 @default.
- W2091052570 hasConceptScore W2091052570C178790620 @default.
- W2091052570 hasConceptScore W2091052570C185592680 @default.
- W2091052570 hasConceptScore W2091052570C27523624 @default.
- W2091052570 hasConceptScore W2091052570C2779134260 @default.
- W2091052570 hasConceptScore W2091052570C2780642029 @default.
- W2091052570 hasConceptScore W2091052570C2994168385 @default.
- W2091052570 hasConceptScore W2091052570C3019447875 @default.
- W2091052570 hasConceptScore W2091052570C71924100 @default.
- W2091052570 hasConceptScore W2091052570C8010536 @default.
- W2091052570 hasConceptScore W2091052570C86803240 @default.
- W2091052570 hasIssue "3" @default.
- W2091052570 hasLocation W20910525701 @default.
- W2091052570 hasOpenAccess W2091052570 @default.
- W2091052570 hasPrimaryLocation W20910525701 @default.
- W2091052570 hasRelatedWork W1499324195 @default.
- W2091052570 hasRelatedWork W1564103972 @default.
- W2091052570 hasRelatedWork W1969275551 @default.
- W2091052570 hasRelatedWork W1997713676 @default.
- W2091052570 hasRelatedWork W2138493935 @default.
- W2091052570 hasRelatedWork W2912083559 @default.
- W2091052570 hasRelatedWork W2952029520 @default.
- W2091052570 hasRelatedWork W3049273506 @default.
- W2091052570 hasRelatedWork W3111093021 @default.
- W2091052570 hasRelatedWork W3158987065 @default.
- W2091052570 hasVolume "100" @default.
- W2091052570 isParatext "false" @default.
- W2091052570 isRetracted "false" @default.
- W2091052570 magId "2091052570" @default.
- W2091052570 workType "article" @default.