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• W2091053357 abstract "The two-state allosteric model of Monod, Wyman and Changeux (1965) offers a simple and elegant, yet very powerful and comprehensive, description of the functional behavior of hemoglobin. Although the extensive body of structural and functional information available is by-and-large consistent with this conceptual framework, some discrepancies between theory and experiment have been extensively discussed and considered to demand modifications of the original hypothesis. More recently the role of tertiary structural changes has been re-analyzed leading to extended kinetic models or indicating that powerful heterotropic effectors may be of paramount importance in controlling the function of human hemoglobin. The aim of this review is to analyze, and possibly reconcile, some discrepancies. We always felt that by looking at hemoglobins other than human HbA, the relative role of tertiary and quaternary allosteric effects may be better understood. The model systems illustrated below are the different hemoglobins from trout's blood, since they are characterized by the most striking variability of heterotropic effects, ranging from totally absent to very extreme with dominant contributions of tertiary effects. This article is part of a Special Issue entitled: Allosteric cooperativity in respiratory proteins." @default.
• W2091053357 created "2016-06-24" @default.
• W2091053357 creator A5076021638 @default.
• W2091053357 creator A5090015641 @default.
• W2091053357 date "2011-10-01" @default.
• W2091053357 modified "2023-10-12" @default.
• W2091053357 title "Hemoglobin allostery: Variations on the theme" @default.
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• W2091053357 doi "https://doi.org/10.1016/j.bbabio.2011.04.004" @default.
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