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- W2091060431 abstract "Certain diquaternarized piperidine derivatives and several bis-tertiary amines were evaluated in the anesthetized rat and dog. The most active hypotensive agents were: 3-mor-pholinopropyl N-methylpipecolinate di-methiodide (JB-643), 2-morpholinoethyl N-methylpipecolinate dimethobromide (JB-654), and beta (3-diethylamino-1-propynyl)-N-methylpiperidine dimethobromide (JB-579). The compounds JB-643 and JB-654, administered orally to unanesthetized dogs, produced marked hypotensive responses persisting for more than eleven hours." @default.
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- W2091060431 date "1960-09-01" @default.
- W2091060431 modified "2023-09-26" @default.
- W2091060431 title "An Evaluation of Certain Hypotensive Agents IV.**University of Pittsburgh, School of Pharmacy, Pittsburgh, Pa." @default.
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- W2091060431 doi "https://doi.org/10.1002/jps.3030490907" @default.
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