FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091065440> ?p ?o ?g. }

• W2091065440 endingPage "14383" @default.
• W2091065440 startingPage "14372" @default.
• W2091065440 abstract "Microsomal triglyceride transfer protein (MTP) is a target to reduce plasma lipids because of its indispensable role in triglyceride-rich lipoprotein biosynthesis. MTP inhibition in Western diet fed mice decreased plasma triglycerides/cholesterol, whereas increasing plasma alanine/aspartate aminotransferases (ALT/AST) and hepatic triglycerides/free cholesterol. Free cholesterol accumulated in the endoplasmic reticulum (ER) and mitochondria resulting in ER and oxidative stresses. Mechanistic studies revealed that MTP inhibition increased transcription of the GPT/GOT1 genes through up-regulation of the IRE1α/cJun pathway leading to increased synthesis and release of ALT1/AST1. Thus, transcriptional up-regulation of GPT/GOT1 genes is a major mechanism, in response to ER stress, elevating plasma transaminases. Increases in plasma and tissue transaminases might represent a normal response to stress for survival." @default.
• W2091065440 created "2016-06-24" @default.
• W2091065440 creator A5007672632 @default.
• W2091065440 creator A5009938916 @default.
• W2091065440 creator A5020123177 @default.
• W2091065440 creator A5035333297 @default.
• W2091065440 creator A5061757710 @default.
• W2091065440 date "2013-05-01" @default.
• W2091065440 modified "2023-10-14" @default.
• W2091065440 title "Microsomal Triglyceride Transfer Protein Inhibition Induces Endoplasmic Reticulum Stress and Increases Gene Transcription via Ire1α/cJun to Enhance Plasma ALT/AST" @default.
• W2091065440 cites W1575045349 @default.
• W2091065440 cites W1977603207 @default.
• W2091065440 cites W1978832277 @default.
• W2091065440 cites W1981460639 @default.
• W2091065440 cites W1984034325 @default.
• W2091065440 cites W1984669204 @default.
• W2091065440 cites W2030031111 @default.
• W2091065440 cites W2032779971 @default.
• W2091065440 cites W2034610817 @default.
• W2091065440 cites W2046959088 @default.
• W2091065440 cites W2058949884 @default.
• W2091065440 cites W2068146999 @default.
• W2091065440 cites W2070053386 @default.
• W2091065440 cites W2079596643 @default.
• W2091065440 cites W2082591499 @default.
• W2091065440 cites W2086516047 @default.
• W2091065440 cites W2088254495 @default.
• W2091065440 cites W2099074546 @default.
• W2091065440 cites W2110804432 @default.
• W2091065440 cites W2114362838 @default.
• W2091065440 cites W2121549194 @default.
• W2091065440 cites W2122345674 @default.
• W2091065440 cites W2123130329 @default.
• W2091065440 cites W2138267862 @default.
• W2091065440 cites W2139168645 @default.
• W2091065440 cites W2142526970 @default.
• W2091065440 cites W2144636739 @default.
• W2091065440 cites W2164737308 @default.
• W2091065440 cites W2167974925 @default.
• W2091065440 cites W2218787476 @default.
• W2091065440 cites W2300552860 @default.
• W2091065440 cites W2321700180 @default.
• W2091065440 cites W4240735590 @default.
• W2091065440 cites W4241939777 @default.
• W2091065440 doi "https://doi.org/10.1074/jbc.m113.459602" @default.
• W2091065440 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3656292" @default.
• W2091065440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23532846" @default.
• W2091065440 hasPublicationYear "2013" @default.
• W2091065440 type Work @default.
• W2091065440 sameAs 2091065440 @default.
• W2091065440 citedByCount "47" @default.
• W2091065440 countsByYear W20910654402013 @default.
• W2091065440 countsByYear W20910654402014 @default.
• W2091065440 countsByYear W20910654402015 @default.
• W2091065440 countsByYear W20910654402016 @default.
• W2091065440 countsByYear W20910654402017 @default.
• W2091065440 countsByYear W20910654402018 @default.
• W2091065440 countsByYear W20910654402019 @default.
• W2091065440 countsByYear W20910654402020 @default.
• W2091065440 countsByYear W20910654402021 @default.
• W2091065440 countsByYear W20910654402022 @default.
• W2091065440 countsByYear W20910654402023 @default.
• W2091065440 crossrefType "journal-article" @default.
• W2091065440 hasAuthorship W2091065440A5007672632 @default.
• W2091065440 hasAuthorship W2091065440A5009938916 @default.
• W2091065440 hasAuthorship W2091065440A5020123177 @default.
• W2091065440 hasAuthorship W2091065440A5035333297 @default.
• W2091065440 hasAuthorship W2091065440A5061757710 @default.
• W2091065440 hasBestOaLocation W20910654401 @default.
• W2091065440 hasConcept C126322002 @default.
• W2091065440 hasConcept C13028836 @default.
• W2091065440 hasConcept C134018914 @default.
• W2091065440 hasConcept C139447449 @default.
• W2091065440 hasConcept C158617107 @default.
• W2091065440 hasConcept C181199279 @default.
• W2091065440 hasConcept C185592680 @default.
• W2091065440 hasConcept C2778163477 @default.
• W2091065440 hasConcept C2778913445 @default.
• W2091065440 hasConcept C2780072125 @default.
• W2091065440 hasConcept C55493867 @default.
• W2091065440 hasConcept C71924100 @default.
• W2091065440 hasConcept C8243546 @default.
• W2091065440 hasConcept C86803240 @default.
• W2091065440 hasConcept C87644729 @default.
• W2091065440 hasConcept C95444343 @default.
• W2091065440 hasConceptScore W2091065440C126322002 @default.
• W2091065440 hasConceptScore W2091065440C13028836 @default.
• W2091065440 hasConceptScore W2091065440C134018914 @default.
• W2091065440 hasConceptScore W2091065440C139447449 @default.
• W2091065440 hasConceptScore W2091065440C158617107 @default.
• W2091065440 hasConceptScore W2091065440C181199279 @default.
• W2091065440 hasConceptScore W2091065440C185592680 @default.
• W2091065440 hasConceptScore W2091065440C2778163477 @default.
• W2091065440 hasConceptScore W2091065440C2778913445 @default.
• W2091065440 hasConceptScore W2091065440C2780072125 @default.
• W2091065440 hasConceptScore W2091065440C55493867 @default.
• W2091065440 hasConceptScore W2091065440C71924100 @default.
• W2091065440 hasConceptScore W2091065440C8243546 @default.

• next