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- W2091078188 abstract "The efficacy of secobarbital sodium plus chlorpromazine (SC) in the prevention of cisplatin induced emesis was compared to the combination of metoclopramide, diphenhydramine, and dexamethasone (MDD). Twenty-three patients were entered onto protocol. Eighteen were evaluable. Good to excellent antiemetic prophylaxis was obtained in 72% with MDD versus 17% with SC (P < 0.01). Sedation and anticholinergic side effects were more common with SC. Extrapyramidal reactions were more commonly seen with MDD. Significantly more patients preferred the combination of metoclopramide, diphenhydramine, and dexamethasone (P < 0.05)." @default.
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- W2091078188 date "1986-08-15" @default.
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- W2091078188 title "The antiemetic efficacy of secobarbital and chlorpromazine compared to metoclopramide, diphenhydramine, and dexamethasone: A randomized trial" @default.
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- W2091078188 doi "https://doi.org/10.1002/1097-0142(19860815)58:4<959::aid-cncr2820580426>3.0.co;2-z" @default.
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