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• W2091083618 abstract "DNA mismatch repair (MMR) within human cells is hypothesized to occur primarily at the replication fork. However, experimental models measuring MMR activity at specific phases of the cell cycle and during genomic DNA synthesis are lacking. We have investigated MMR activity within the nuclear environment of HeLa cells after enriching for G1, S and G2/M phase of the cell cycle by centrifugal elutriation. This approach preserves physiologically normal MMR activity in cell populations subdivided into different phases of the cell cycle. Here we have shown that nuclear protein concentration of hMutSα and hMutLα increases as cells progress into S phase during routine cell culture. MMR activity, as measured by both in vitro and in vivo approaches, increases during S phase to the highest extent within normally growing cells. Both fidelity and activity of MMR are highest on actively replicating templates within intact cells during S phase. The MMR pathway however, is also active at lower levels at other phases of the cell cycle, and on nonreplicating templates." @default.
• W2091083618 created "2016-06-24" @default.
• W2091083618 creator A5010495823 @default.
• W2091083618 creator A5075527344 @default.
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• W2091083618 date "2009-03-01" @default.
• W2091083618 modified "2023-10-18" @default.
• W2091083618 title "DNA mismatch repair efficiency and fidelity are elevated during DNA synthesis in human cells" @default.
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• W2091083618 doi "https://doi.org/10.1016/j.mrfmmm.2008.12.006" @default.
• W2091083618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2649689" @default.
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