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- W2091087670 abstract "The presentation of antigen in a form that can be recognized by T lymphocytes of the immune system requires antigen processing and association of antigen-derived fragments with molecules encoded by the major histocompatibility complex (MHC) locus or by the CD1 locus. Much emphasis on antigen processing and presentation in the last decades has focused on what we consider 'conventional routes' of antigen processing and presentation, whereby extracellular antigens are processed for presentation via Class II MHC complexes and cytosolic antigens are presented as peptide-Class I MHC complexes. We here highlight two other pathways in myeloid dendritic cells, those of lipid antigen presentation in association with CD1 and of peptide cross-presentation via Class I MHC complexes. Some pathogens evade immune recognition through inhibition of antigen presentation of phagosomal origin. Deviations in endosomal antigen processing and presentation are also seen in individuals suffering from glycosphingolipid lysosomal lipid storage diseases. We summarize recent developments in the endosomal antigen processing and presentation pathway, for display as lipid-CD1 complexes to natural killer T cells and as peptide-Class I MHC complexes to CD8 T cells." @default.
- W2091087670 created "2016-06-24" @default.
- W2091087670 creator A5036407951 @default.
- W2091087670 creator A5041153123 @default.
- W2091087670 creator A5076144893 @default.
- W2091087670 date "2009-06-01" @default.
- W2091087670 modified "2023-09-27" @default.
- W2091087670 title "Endosomal processing for antigen presentation mediated by CD1 and Class I major histocompatibility complex: roads to display or destruction" @default.
- W2091087670 cites W1527192915 @default.
- W2091087670 cites W1559523991 @default.
- W2091087670 cites W1577102950 @default.
- W2091087670 cites W1627868131 @default.
- W2091087670 cites W1661544713 @default.
- W2091087670 cites W1964168671 @default.
- W2091087670 cites W1967546883 @default.
- W2091087670 cites W1967631629 @default.
- W2091087670 cites W1968182403 @default.
- W2091087670 cites W1973362572 @default.
- W2091087670 cites W1977812921 @default.
- W2091087670 cites W1981718801 @default.
- W2091087670 cites W1985498297 @default.
- W2091087670 cites W1986263202 @default.
- W2091087670 cites W1988869609 @default.
- W2091087670 cites W1994505708 @default.
- W2091087670 cites W1997276741 @default.
- W2091087670 cites W1999436383 @default.
- W2091087670 cites W2000952771 @default.
- W2091087670 cites W2008626549 @default.
- W2091087670 cites W2009703634 @default.
- W2091087670 cites W2013255473 @default.
- W2091087670 cites W2013660817 @default.
- W2091087670 cites W2013829335 @default.
- W2091087670 cites W2013857975 @default.
- W2091087670 cites W2015373718 @default.
- W2091087670 cites W2016635886 @default.
- W2091087670 cites W2016697702 @default.
- W2091087670 cites W2017816736 @default.
- W2091087670 cites W2020795276 @default.
- W2091087670 cites W2021673674 @default.
- W2091087670 cites W2024543747 @default.
- W2091087670 cites W2026341611 @default.
- W2091087670 cites W2027047782 @default.
- W2091087670 cites W2032940947 @default.
- W2091087670 cites W2038663100 @default.
- W2091087670 cites W2040086516 @default.
- W2091087670 cites W2040087470 @default.
- W2091087670 cites W2042411369 @default.
- W2091087670 cites W2044866503 @default.
- W2091087670 cites W2050700926 @default.
- W2091087670 cites W2052997401 @default.
- W2091087670 cites W2053088462 @default.
- W2091087670 cites W2057673313 @default.
- W2091087670 cites W2058015480 @default.
- W2091087670 cites W2061060052 @default.
- W2091087670 cites W2061203855 @default.
- W2091087670 cites W2061344384 @default.
- W2091087670 cites W2061503084 @default.
- W2091087670 cites W2062619192 @default.
- W2091087670 cites W2064794064 @default.
- W2091087670 cites W2068853695 @default.
- W2091087670 cites W2069556438 @default.
- W2091087670 cites W2075908603 @default.
- W2091087670 cites W2076024275 @default.
- W2091087670 cites W2076272357 @default.
- W2091087670 cites W2078923786 @default.
- W2091087670 cites W2081287274 @default.
- W2091087670 cites W2087106927 @default.
- W2091087670 cites W2090645887 @default.
- W2091087670 cites W2092325349 @default.
- W2091087670 cites W2094854776 @default.
- W2091087670 cites W2098084836 @default.
- W2091087670 cites W2100382777 @default.
- W2091087670 cites W2104595633 @default.
- W2091087670 cites W2105266773 @default.
- W2091087670 cites W2105952229 @default.
- W2091087670 cites W2110365405 @default.
- W2091087670 cites W2111428445 @default.
- W2091087670 cites W2116156361 @default.
- W2091087670 cites W2117404315 @default.
- W2091087670 cites W2119764013 @default.
- W2091087670 cites W2121113374 @default.
- W2091087670 cites W2121477549 @default.
- W2091087670 cites W2121968955 @default.
- W2091087670 cites W2122635106 @default.
- W2091087670 cites W2127022761 @default.
- W2091087670 cites W2127404676 @default.
- W2091087670 cites W2127782698 @default.
- W2091087670 cites W2128631964 @default.
- W2091087670 cites W2129990560 @default.
- W2091087670 cites W2131000952 @default.
- W2091087670 cites W2133040249 @default.
- W2091087670 cites W2134735862 @default.
- W2091087670 cites W2134881264 @default.
- W2091087670 cites W2135192028 @default.
- W2091087670 cites W2135662331 @default.
- W2091087670 cites W2137490005 @default.
- W2091087670 cites W2139115350 @default.
- W2091087670 cites W2141753982 @default.