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- W2091098678 abstract "RATIONALE: To investigate whether symptomatic treatment with an oral extended-release (ER) combination expectorant and decongestant product (guaifenesin [G] and pseudoephedrine HCl [PSE]) can improve quality of life in patients with URI. METHODS: Patients aged 18-75 years with symptoms of an acute URI were randomized within 5 days of onset to G 1200mg + PSE 120mg ER bi-layer tablets (ER G+PSE, Mucinex® D), or matching placebo, b.i.d. for 7 days. Eligible patients had a total respiratory symptom score ≥12 (>34%). Quality of life was evaluated via the WURSS-21 questionnaire, a validated illness-specific questionnaire designed to reflect outcomes important to people with colds and measure items that change over time. RESULTS: 1189 patients were enrolled; data are reported for the modified intent-to-treat population (n=1179). Statistically significant improvements were seen in the WURSS-21 Total Score, Total Symptom Score, and Total Functional Score with ER G+PSE vs. placebo from baseline to Day 4 (p=0.024, p=0.013, p=0.050, respectively), but not on Day 8. Individual WURSS-21 scores on Day 4 were significantly in favor of ER G+PSE vs. placebo for 9 symptoms (runny nose; sneezing; scratchy throat; hoarseness; head congestion; think clearly; breathe easily; walk, climb stairs, exercise; interaction with others). Although the proportion of patients experiencing overall relief at Day 4 pm (primary endpoint) was not significantly different between groups (p=0.441), desire for antibiotics at Day 8 was significantly reduced with ER G+PSE (p=0.008). CONCLUSIONS: Patients receiving ER G+PSE as first-line symptomatic treatment for URI report improved quality of life vs. placebo 4 days after starting treatment (p=0.024)." @default.
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- W2091098678 date "2011-02-01" @default.
- W2091098678 modified "2023-09-25" @default.
- W2091098678 title "Quality Of Life In Patients Taking Guaifenesin And Pseudoephedrine In An Extended-release Bi-layer Tablet As First-line Symptomatic Therapy For Acute Upper Respiratory Tract Infections (URI)" @default.
- W2091098678 doi "https://doi.org/10.1016/j.jaci.2010.12.801" @default.
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