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• W2091102945 abstract "In order to examine whether ATP-sensitive potassium channel Kir6.2 is involved in hypoxic ventilatory responses, especially in hypoxic ventilatory depression (HVD), and whether the involvement shows age-dependence, we measured the hypoxic ventilatory response in the Kir6.2-knockout mouse (Kir6.2−/−) in an unanesthetized unrestrained state by means of pressure plethysmography in the 2nd and 4th postnatal weeks, and compared the response with that of its wild type counterpart, the C57BL6/J mouse. In the 4th postnatal week, but not in the 2nd week, the Kir6.2−/− exhibited a larger and longer initial augmentation and a weaker subsequent depression of respiratory frequency and ventilation in response to hypoxia (FIO2 = 0.12 in N2). These findings suggest that Kir6.2 is involved in HVD of the mouse at a certain point during the postnatal development." @default.
• W2091102945 created "2016-06-24" @default.
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• W2091102945 date "2008-06-01" @default.
• W2091102945 modified "2023-10-15" @default.
• W2091102945 title "Age-dependent involvement of ATP-sensitive potassium channel Kir6.2 in hypoxic ventilatory depression of mouse" @default.
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• W2091102945 doi "https://doi.org/10.1016/j.resp.2008.04.003" @default.
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