FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091103306> ?p ?o ?g. }

• W2091103306 endingPage "601" @default.
• W2091103306 startingPage "593" @default.
• W2091103306 abstract "Polycystin-2, a member of the TRP family of calcium channels, is encoded by the human PKD2 gene. Mutations in that gene can lead to swelling of nephrons into the fluid-filled cysts of polycystic kidney disease. In addition to expression in tubular epithelial cells, human polycystin-2 is found in muscle and neuronal cells, but its cell biological function has been unclear. A homologue in Caenorhabditis elegans is necessary for male mating behavior. We compared the behavior, calcium signaling mechanisms, and electrophysiology of wild-type and pkd-2 knockout C. elegans. In addition to characterizing PKD-2-mediated aggregation and mating behaviors, we found that polycystin-2 is an intracellular Ca(2+) release channel that is required for the normal pattern of Ca(2+) responses involving IP(3) and ryanodine receptor-mediated Ca(2+) release from intracellular stores. Activity of polycystin-2 creates brief cytosolic Ca(2+) transients with increased amplitude and decreased duration. Polycystin-2, along with the IP(3) and ryanodine receptors, acts as a major calcium-release channel in the endoplasmic reticulum in cells where rapid calcium signaling is required, and polycystin-2 activity is essential in those excitable cells for rapid responses to stimuli." @default.
• W2091103306 created "2016-06-24" @default.
• W2091103306 creator A5000853968 @default.
• W2091103306 creator A5009291181 @default.
• W2091103306 creator A5011135582 @default.
• W2091103306 creator A5012691452 @default.
• W2091103306 creator A5015161752 @default.
• W2091103306 creator A5028920280 @default.
• W2091103306 creator A5039398340 @default.
• W2091103306 creator A5067241155 @default.
• W2091103306 creator A5090373804 @default.
• W2091103306 date "2005-06-01" @default.
• W2091103306 modified "2023-09-26" @default.
• W2091103306 title "Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans" @default.
• W2091103306 cites W1492104840 @default.
• W2091103306 cites W1724440031 @default.
• W2091103306 cites W1966685035 @default.
• W2091103306 cites W1969212379 @default.
• W2091103306 cites W1976989450 @default.
• W2091103306 cites W1982226533 @default.
• W2091103306 cites W2001627351 @default.
• W2091103306 cites W2002859651 @default.
• W2091103306 cites W2002908018 @default.
• W2091103306 cites W2005026678 @default.
• W2091103306 cites W2006380829 @default.
• W2091103306 cites W2007690061 @default.
• W2091103306 cites W2012954001 @default.
• W2091103306 cites W2014264816 @default.
• W2091103306 cites W2014604277 @default.
• W2091103306 cites W2027351968 @default.
• W2091103306 cites W2033243150 @default.
• W2091103306 cites W2040664792 @default.
• W2091103306 cites W2075591864 @default.
• W2091103306 cites W2101166125 @default.
• W2091103306 cites W2103377139 @default.
• W2091103306 cites W2136875701 @default.
• W2091103306 cites W2147677687 @default.
• W2091103306 cites W2154113357 @default.
• W2091103306 cites W2164020057 @default.
• W2091103306 cites W2166718853 @default.
• W2091103306 doi "https://doi.org/10.1016/j.ceca.2005.03.003" @default.
• W2091103306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15862350" @default.
• W2091103306 hasPublicationYear "2005" @default.
• W2091103306 type Work @default.
• W2091103306 sameAs 2091103306 @default.
• W2091103306 citedByCount "26" @default.
• W2091103306 countsByYear W20911033062012 @default.
• W2091103306 countsByYear W20911033062014 @default.
• W2091103306 countsByYear W20911033062015 @default.
• W2091103306 countsByYear W20911033062016 @default.
• W2091103306 countsByYear W20911033062018 @default.
• W2091103306 crossrefType "journal-article" @default.
• W2091103306 hasAuthorship W2091103306A5000853968 @default.
• W2091103306 hasAuthorship W2091103306A5009291181 @default.
• W2091103306 hasAuthorship W2091103306A5011135582 @default.
• W2091103306 hasAuthorship W2091103306A5012691452 @default.
• W2091103306 hasAuthorship W2091103306A5015161752 @default.
• W2091103306 hasAuthorship W2091103306A5028920280 @default.
• W2091103306 hasAuthorship W2091103306A5039398340 @default.
• W2091103306 hasAuthorship W2091103306A5067241155 @default.
• W2091103306 hasAuthorship W2091103306A5090373804 @default.
• W2091103306 hasConcept C104317684 @default.
• W2091103306 hasConcept C113217602 @default.
• W2091103306 hasConcept C152624196 @default.
• W2091103306 hasConcept C158617107 @default.
• W2091103306 hasConcept C170493617 @default.
• W2091103306 hasConcept C178790620 @default.
• W2091103306 hasConcept C181080969 @default.
• W2091103306 hasConcept C185592680 @default.
• W2091103306 hasConcept C18699975 @default.
• W2091103306 hasConcept C201571599 @default.
• W2091103306 hasConcept C2777427919 @default.
• W2091103306 hasConcept C2778944004 @default.
• W2091103306 hasConcept C519063684 @default.
• W2091103306 hasConcept C55493867 @default.
• W2091103306 hasConcept C62478195 @default.
• W2091103306 hasConcept C79879829 @default.
• W2091103306 hasConcept C86803240 @default.
• W2091103306 hasConcept C95444343 @default.
• W2091103306 hasConceptScore W2091103306C104317684 @default.
• W2091103306 hasConceptScore W2091103306C113217602 @default.
• W2091103306 hasConceptScore W2091103306C152624196 @default.
• W2091103306 hasConceptScore W2091103306C158617107 @default.
• W2091103306 hasConceptScore W2091103306C170493617 @default.
• W2091103306 hasConceptScore W2091103306C178790620 @default.
• W2091103306 hasConceptScore W2091103306C181080969 @default.
• W2091103306 hasConceptScore W2091103306C185592680 @default.
• W2091103306 hasConceptScore W2091103306C18699975 @default.
• W2091103306 hasConceptScore W2091103306C201571599 @default.
• W2091103306 hasConceptScore W2091103306C2777427919 @default.
• W2091103306 hasConceptScore W2091103306C2778944004 @default.
• W2091103306 hasConceptScore W2091103306C519063684 @default.
• W2091103306 hasConceptScore W2091103306C55493867 @default.
• W2091103306 hasConceptScore W2091103306C62478195 @default.
• W2091103306 hasConceptScore W2091103306C79879829 @default.
• W2091103306 hasConceptScore W2091103306C86803240 @default.
• W2091103306 hasConceptScore W2091103306C95444343 @default.
• W2091103306 hasIssue "6" @default.

• next