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- W2091103586 abstract "Gentamicin sulfate, a mixture of aminoglycoside type antibiotics applied in veterinary practice, was entrapped in a protein cover in order to prevent its decomposition before absorption from the gastroin testinal system. Unpurified egg albumin was used for this purpose. For detection of the drug a fluorescence label was introduced. The microparticles were prepared by a heat stabilization method in a water/oil system. The drug-release was checked in in vitro experiments. Since the drug retaining ability of the microspheres was not satisfactory after this procedure, further hardening was accomplished by chemical crosslinks which were induced with glutaraldehyde. We have examined the effect of changes in different parameters of the synthesis on the drug-retaining ability of produced microcapsules. We have produced microspheres which hold about 80% of entrapped material even after 4 h at pH 7,2, which corresponds to the conditions in saliva and rumen of animals but having reached the stomach they presumably release the total amount of the drug." @default.
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- W2091103586 date "1993-05-01" @default.
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- W2091103586 title "Preparation of egg albumin microparticles for oral application" @default.
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- W2091103586 doi "https://doi.org/10.1016/0168-3659(93)90099-q" @default.
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