Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091109247> ?p ?o ?g. }
- W2091109247 endingPage "25" @default.
- W2091109247 startingPage "10" @default.
- W2091109247 abstract "This study systematically evaluates the effects of androgen receptor (AR) blockade on molecular events in Leydig cells. Results showed that intramuscular administration of testosterone-enanthate, at clinically relevant dose, decreased testosterone in interstitial fluid and Leydig cells from adult rats. AR-blocker (Androcur) prevented this effect and testosterone-reduced Leydig cells steroidogenic capacity/activity. Testosterone-reduced expression of some steroidogenic enzymes/proteins (Tspo,StAR,Hsd3b1/2) and transcription factors (Nur77,Gata4,Dax1) was completely abrogated, while decreased expression of Star,Cyp11a1,Cyp17a1,Hsd17b4,Creb1a was partially prevented. In the same cells, increased expression of Hsd3b5/HSD3B and Ar/AR was abolished. Androcur-treatment abolished testosterone-reduced cAMP, coupled with a changed expressional milieu of cAMP signaling elements. Results from in vitro experiments suggest that some of these effects are testosterone-AR dependent, while others could be due to disturbed LH and/or other signals. Presented data provide new molecular insight into Leydig cells function and are important in terms of human reproductive health and the wide-spread use of Androcur as well as use/abuse of testosterone-enanthate." @default.
- W2091109247 created "2016-06-24" @default.
- W2091109247 creator A5028183186 @default.
- W2091109247 creator A5030533453 @default.
- W2091109247 creator A5032142710 @default.
- W2091109247 creator A5046036271 @default.
- W2091109247 creator A5053129015 @default.
- W2091109247 creator A5065568552 @default.
- W2091109247 creator A5087636929 @default.
- W2091109247 creator A5091428600 @default.
- W2091109247 date "2014-10-01" @default.
- W2091109247 modified "2023-10-05" @default.
- W2091109247 title "Molecular adaptations of testosterone-producing Leydig cells during systemic in vivo blockade of the androgen receptor" @default.
- W2091109247 cites W143316374 @default.
- W2091109247 cites W1486788208 @default.
- W2091109247 cites W1493663903 @default.
- W2091109247 cites W1610204701 @default.
- W2091109247 cites W1970594643 @default.
- W2091109247 cites W1978013981 @default.
- W2091109247 cites W1980515518 @default.
- W2091109247 cites W1981234399 @default.
- W2091109247 cites W1985665219 @default.
- W2091109247 cites W1986524209 @default.
- W2091109247 cites W1986886291 @default.
- W2091109247 cites W1987731862 @default.
- W2091109247 cites W1990094934 @default.
- W2091109247 cites W1990355134 @default.
- W2091109247 cites W1990367576 @default.
- W2091109247 cites W2002821147 @default.
- W2091109247 cites W2011908174 @default.
- W2091109247 cites W2013726996 @default.
- W2091109247 cites W2017569474 @default.
- W2091109247 cites W2020663303 @default.
- W2091109247 cites W2032754168 @default.
- W2091109247 cites W2035362985 @default.
- W2091109247 cites W2039154844 @default.
- W2091109247 cites W2040877330 @default.
- W2091109247 cites W2042278208 @default.
- W2091109247 cites W2045461552 @default.
- W2091109247 cites W2046679439 @default.
- W2091109247 cites W2054112803 @default.
- W2091109247 cites W2054961865 @default.
- W2091109247 cites W2056752882 @default.
- W2091109247 cites W2057444217 @default.
- W2091109247 cites W2059266306 @default.
- W2091109247 cites W2060032158 @default.
- W2091109247 cites W2061236466 @default.
- W2091109247 cites W2061564710 @default.
- W2091109247 cites W2065983848 @default.
- W2091109247 cites W2074941721 @default.
- W2091109247 cites W2080086312 @default.
- W2091109247 cites W2082237694 @default.
- W2091109247 cites W2086970328 @default.
- W2091109247 cites W2091229782 @default.
- W2091109247 cites W2095471601 @default.
- W2091109247 cites W2096594220 @default.
- W2091109247 cites W2096750882 @default.
- W2091109247 cites W2103518814 @default.
- W2091109247 cites W2106343960 @default.
- W2091109247 cites W2107991694 @default.
- W2091109247 cites W2109494488 @default.
- W2091109247 cites W2113065336 @default.
- W2091109247 cites W2117278034 @default.
- W2091109247 cites W2122149276 @default.
- W2091109247 cites W2125508388 @default.
- W2091109247 cites W2126846194 @default.
- W2091109247 cites W2134876608 @default.
- W2091109247 cites W2136706063 @default.
- W2091109247 cites W2137346714 @default.
- W2091109247 cites W2137640328 @default.
- W2091109247 cites W2139309276 @default.
- W2091109247 cites W2139767645 @default.
- W2091109247 cites W2142392228 @default.
- W2091109247 cites W2142563833 @default.
- W2091109247 cites W2142623609 @default.
- W2091109247 cites W2145820822 @default.
- W2091109247 cites W2146672281 @default.
- W2091109247 cites W2148120442 @default.
- W2091109247 cites W2151899500 @default.
- W2091109247 cites W2154590674 @default.
- W2091109247 cites W2160398712 @default.
- W2091109247 cites W2165196024 @default.
- W2091109247 cites W2166095387 @default.
- W2091109247 cites W2326289669 @default.
- W2091109247 cites W2332140839 @default.
- W2091109247 cites W2337383522 @default.
- W2091109247 cites W4236576548 @default.
- W2091109247 doi "https://doi.org/10.1016/j.mce.2014.08.007" @default.
- W2091109247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25153259" @default.
- W2091109247 hasPublicationYear "2014" @default.
- W2091109247 type Work @default.
- W2091109247 sameAs 2091109247 @default.
- W2091109247 citedByCount "12" @default.
- W2091109247 countsByYear W20911092472015 @default.
- W2091109247 countsByYear W20911092472016 @default.
- W2091109247 countsByYear W20911092472017 @default.
- W2091109247 countsByYear W20911092472019 @default.
- W2091109247 countsByYear W20911092472020 @default.