FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091111786> ?p ?o ?g. }

• W2091111786 endingPage "132" @default.
• W2091111786 startingPage "124" @default.
• W2091111786 abstract "It is well established that growth hormone (GH) and granins are co-stored and co-secreted from pituitary somatotrophs. In this work we demonstrate for the first time that GH- and secretoneurin (SN) immunoreactivity (the secretogranin II (SgII) fragment) are similarly present in retinal ganglion cells (RGCs), which is an extrapituitary site of GH expression, and in quail QNR/D cells, which provide an experimental RGC model. The expression of SgII and chromogranin A in the pituitary gland, neuroretina and QNR/D cells was confirmed by RT-PCR analysis. Western blotting also showed that the SN-immunoreactivity in somatotrophs and QNR/D cells was associated with multiple protein bands (24, 35, 48, 72, 78, 93 and 148 kDa) of which the 72 kDa and 148 kDa bands were most abundant. Secretoneurin was constitutively secreted from QNR/D cells as 35 kDa and 37 kDa proteins and unlike GH, was not increased by exogenous GH-releasing hormone (GHRH). Intracellular analysis by EM showed co-localization of GH and SN in cell bodies and neurites in QNR/D cells. This co-localization was associated with small dark bodies in the neurites. In addition, co-localization of GH and SNAP-25 in the cell surface of QNR/D’s plasma membranes suggests GH-release involves specific vesicle-membrane recognition in QNR/D cells. As SN is a marker for secretory granules, GH secretion from RGCs is thus likely to be in secretory granules, as in somatotrophs." @default.
• W2091111786 created "2016-06-24" @default.
• W2091111786 creator A5004819710 @default.
• W2091111786 creator A5044943603 @default.
• W2091111786 creator A5051649380 @default.
• W2091111786 date "2015-09-01" @default.
• W2091111786 modified "2023-10-18" @default.
• W2091111786 title "Co-storage and secretion of growth hormone and secretoneurin in retinal ganglion cells" @default.
• W2091111786 cites W1972940909 @default.
• W2091111786 cites W1977934005 @default.
• W2091111786 cites W1980434142 @default.
• W2091111786 cites W1984557564 @default.
• W2091111786 cites W1988436673 @default.
• W2091111786 cites W1991762620 @default.
• W2091111786 cites W1992670500 @default.
• W2091111786 cites W1993215622 @default.
• W2091111786 cites W1997011917 @default.
• W2091111786 cites W1997727954 @default.
• W2091111786 cites W2004778655 @default.
• W2091111786 cites W2006266851 @default.
• W2091111786 cites W2020109922 @default.
• W2091111786 cites W2023474376 @default.
• W2091111786 cites W2027639096 @default.
• W2091111786 cites W2029110222 @default.
• W2091111786 cites W2030492631 @default.
• W2091111786 cites W2030659712 @default.
• W2091111786 cites W2034965928 @default.
• W2091111786 cites W2040866860 @default.
• W2091111786 cites W2044598733 @default.
• W2091111786 cites W2046299306 @default.
• W2091111786 cites W2062013440 @default.
• W2091111786 cites W2064418240 @default.
• W2091111786 cites W2066749726 @default.
• W2091111786 cites W2074268427 @default.
• W2091111786 cites W2081944866 @default.
• W2091111786 cites W2087621358 @default.
• W2091111786 cites W2090795299 @default.
• W2091111786 cites W2116803802 @default.
• W2091111786 cites W2127513830 @default.
• W2091111786 cites W2132594641 @default.
• W2091111786 cites W2150005048 @default.
• W2091111786 cites W2153623813 @default.
• W2091111786 cites W2156927658 @default.
• W2091111786 cites W2157235270 @default.
• W2091111786 cites W4249378679 @default.
• W2091111786 doi "https://doi.org/10.1016/j.ygcen.2014.11.012" @default.
• W2091111786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25435278" @default.
• W2091111786 hasPublicationYear "2015" @default.
• W2091111786 type Work @default.
• W2091111786 sameAs 2091111786 @default.
• W2091111786 citedByCount "8" @default.
• W2091111786 countsByYear W20911117862016 @default.
• W2091111786 countsByYear W20911117862017 @default.
• W2091111786 countsByYear W20911117862018 @default.
• W2091111786 countsByYear W20911117862019 @default.
• W2091111786 countsByYear W20911117862021 @default.
• W2091111786 crossrefType "journal-article" @default.
• W2091111786 hasAuthorship W2091111786A5004819710 @default.
• W2091111786 hasAuthorship W2091111786A5044943603 @default.
• W2091111786 hasAuthorship W2091111786A5051649380 @default.
• W2091111786 hasConcept C113246987 @default.
• W2091111786 hasConcept C126322002 @default.
• W2091111786 hasConcept C134018914 @default.
• W2091111786 hasConcept C202751555 @default.
• W2091111786 hasConcept C203014093 @default.
• W2091111786 hasConcept C204232928 @default.
• W2091111786 hasConcept C2777658017 @default.
• W2091111786 hasConcept C49039625 @default.
• W2091111786 hasConcept C55493867 @default.
• W2091111786 hasConcept C71315377 @default.
• W2091111786 hasConcept C71924100 @default.
• W2091111786 hasConcept C77231918 @default.
• W2091111786 hasConcept C86803240 @default.
• W2091111786 hasConcept C94984642 @default.
• W2091111786 hasConcept C95444343 @default.
• W2091111786 hasConceptScore W2091111786C113246987 @default.
• W2091111786 hasConceptScore W2091111786C126322002 @default.
• W2091111786 hasConceptScore W2091111786C134018914 @default.
• W2091111786 hasConceptScore W2091111786C202751555 @default.
• W2091111786 hasConceptScore W2091111786C203014093 @default.
• W2091111786 hasConceptScore W2091111786C204232928 @default.
• W2091111786 hasConceptScore W2091111786C2777658017 @default.
• W2091111786 hasConceptScore W2091111786C49039625 @default.
• W2091111786 hasConceptScore W2091111786C55493867 @default.
• W2091111786 hasConceptScore W2091111786C71315377 @default.
• W2091111786 hasConceptScore W2091111786C71924100 @default.
• W2091111786 hasConceptScore W2091111786C77231918 @default.
• W2091111786 hasConceptScore W2091111786C86803240 @default.
• W2091111786 hasConceptScore W2091111786C94984642 @default.
• W2091111786 hasConceptScore W2091111786C95444343 @default.
• W2091111786 hasFunder F4320334593 @default.
• W2091111786 hasLocation W20911117861 @default.
• W2091111786 hasLocation W20911117862 @default.
• W2091111786 hasOpenAccess W2091111786 @default.
• W2091111786 hasPrimaryLocation W20911117861 @default.
• W2091111786 hasRelatedWork W2022001512 @default.
• W2091111786 hasRelatedWork W2027754564 @default.
• W2091111786 hasRelatedWork W2033891528 @default.

• next