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- W2091141707 abstract "One of the most important protein complexes involved in maintaining correct RNA levels in eukaryotic cells is the exosome, a complex consisting almost exclusively of exoribonucleolytic proteins. Since the identification of the exosome complex, seven years ago, much progress has been made in the characterization of its composition, structure and function in a variety of organisms. Although the exosome seems to accumulate in the nucleolus, it has been clearly established that it is also localized in cytoplasm and nucleoplasm. In accordance with its widespread intracellular distribution, the exosome has been implicated in a variety of RNA processing and degradation processes. Nevertheless, many questions still remain unanswered. What are the factors that regulate the activity of the exosome? How and where is the complex assembled? What are the differences in the composition of the nuclear and cytoplasmic exosome? What is the detailed structure of exosome subunits? What are the mechanisms by which the exosome is recruited to substrate RNAs? Here, we summarize the current knowledge on the composition and architecture of this complex, explain its role in both the production and degradation of various types of RNA molecules and discuss the implications of recent research developments that shed some light on the questions above and the mechanisms that are controlling the exosome." @default.
- W2091141707 created "2016-06-24" @default.
- W2091141707 creator A5005494840 @default.
- W2091141707 creator A5016205726 @default.
- W2091141707 creator A5081889079 @default.
- W2091141707 date "2004-01-01" @default.
- W2091141707 modified "2023-09-27" @default.
- W2091141707 title "The exosome, a molecular machine for controlled RNA degradation in both nucleus and cytoplasm" @default.
- W2091141707 cites W1524542249 @default.
- W2091141707 cites W164713944 @default.
- W2091141707 cites W1811811248 @default.
- W2091141707 cites W1868878200 @default.
- W2091141707 cites W1889489351 @default.
- W2091141707 cites W1903251151 @default.
- W2091141707 cites W1973255990 @default.
- W2091141707 cites W1974575813 @default.
- W2091141707 cites W1983136047 @default.
- W2091141707 cites W1989579432 @default.
- W2091141707 cites W1995383880 @default.
- W2091141707 cites W1995452469 @default.
- W2091141707 cites W2000135114 @default.
- W2091141707 cites W2005982219 @default.
- W2091141707 cites W2007781782 @default.
- W2091141707 cites W2008188499 @default.
- W2091141707 cites W2010325815 @default.
- W2091141707 cites W2011339621 @default.
- W2091141707 cites W2011984060 @default.
- W2091141707 cites W2014242307 @default.
- W2091141707 cites W2027284945 @default.
- W2091141707 cites W2028009985 @default.
- W2091141707 cites W2028061670 @default.
- W2091141707 cites W2028513775 @default.
- W2091141707 cites W2032747482 @default.
- W2091141707 cites W2034276590 @default.
- W2091141707 cites W2034937411 @default.
- W2091141707 cites W2040010148 @default.
- W2091141707 cites W2041282675 @default.
- W2091141707 cites W2041583688 @default.
- W2091141707 cites W2042104697 @default.
- W2091141707 cites W2044386270 @default.
- W2091141707 cites W2048870226 @default.
- W2091141707 cites W2055099935 @default.
- W2091141707 cites W2055387854 @default.
- W2091141707 cites W2057702463 @default.
- W2091141707 cites W2057850271 @default.
- W2091141707 cites W2065304353 @default.
- W2091141707 cites W2066680383 @default.
- W2091141707 cites W2070536934 @default.
- W2091141707 cites W2071914120 @default.
- W2091141707 cites W2073109959 @default.
- W2091141707 cites W2078906823 @default.
- W2091141707 cites W2079810511 @default.
- W2091141707 cites W2081056759 @default.
- W2091141707 cites W2082234270 @default.
- W2091141707 cites W2082514511 @default.
- W2091141707 cites W2084619201 @default.
- W2091141707 cites W2089298482 @default.
- W2091141707 cites W2096909079 @default.
- W2091141707 cites W2099425292 @default.
- W2091141707 cites W2099657885 @default.
- W2091141707 cites W2100269820 @default.
- W2091141707 cites W2110544609 @default.
- W2091141707 cites W2111369118 @default.
- W2091141707 cites W2111624324 @default.
- W2091141707 cites W2112163804 @default.
- W2091141707 cites W2117764830 @default.
- W2091141707 cites W2120959840 @default.
- W2091141707 cites W2123577912 @default.
- W2091141707 cites W2125652836 @default.
- W2091141707 cites W2125762953 @default.
- W2091141707 cites W2126349804 @default.
- W2091141707 cites W2129232563 @default.
- W2091141707 cites W2130443336 @default.
- W2091141707 cites W2133176364 @default.
- W2091141707 cites W2135271145 @default.
- W2091141707 cites W2137607173 @default.
- W2091141707 cites W2138524348 @default.
- W2091141707 cites W2146393576 @default.
- W2091141707 cites W2147055704 @default.
- W2091141707 cites W2150014428 @default.
- W2091141707 cites W2151992425 @default.
- W2091141707 cites W2152432732 @default.
- W2091141707 cites W2152656750 @default.
- W2091141707 cites W2157099873 @default.
- W2091141707 cites W2166925934 @default.
- W2091141707 cites W2169525767 @default.
- W2091141707 cites W4230807179 @default.
- W2091141707 cites W4297791699 @default.
- W2091141707 doi "https://doi.org/10.1078/0171-9335-00385" @default.
- W2091141707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15346807" @default.
- W2091141707 hasPublicationYear "2004" @default.
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