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• W2091170111 abstract "We have previously reported that administration of Thymosin alpha 1 (T-α1) can enhance the level of the Nerve Growth Factor and the distribution of its receptor in the developing Central Nervous System (CNS) of rat. To further explore the role of T-α1 and verify its presence in cells of rat CNS, we carried out an immunohistochemical study using a polyclonal antibody against T-α1. T-α1 immunoreactivity was found mainly in neurons of the hippocampus and spinal cord and in several small cells, resembling glial cells, of specific regions of the brain. Moreover, to study whether cerebral cells were receptive to T-α1, we injected iodinated T-α1 (125I-T-α1) icv. 125I-T-α1 labelled neurons were observed in the hypothalamus and septal nuclei. Our results indicate that specific neuronal populations in the rat CNS are able to express and respond to T-α1." @default.
• W2091170111 created "2016-06-24" @default.
• W2091170111 creator A5018870384 @default.
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• W2091170111 date "1999-12-01" @default.
• W2091170111 modified "2023-09-30" @default.
• W2091170111 title "Evidence that endogenous thymosin alpha-1 is present in the rat central nervous system" @default.
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• W2091170111 doi "https://doi.org/10.1016/s0197-0186(99)00084-4" @default.
• W2091170111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10524714" @default.
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