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• W2091173774 abstract "Abstract Iminoboronates have been utilized to successfully install azide and alkyne bioorthogonal functions on proteins, which may then be further reacted with their bioorthogonal counterparts. These constructs were also used to add polyethylene glycol (PEG) to insulin, a modification which has been shown to be reversible in the presence of fructose. Finally, iminoboronates were used to assemble a folic acid/paclitaxel small‐molecule/drug conjugate in situ with an IC 50 value of 20.7 n M against NCI‐H460 cancer cells and negligible cytotoxicity against the CRL‐1502 noncancer cells." @default.
• W2091173774 created "2016-06-24" @default.
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• W2091173774 date "2015-04-20" @default.
• W2091173774 modified "2023-10-18" @default.
• W2091173774 title "Reversible Lysine Modification on Proteins by Using Functionalized Boronic Acids" @default.
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• W2091173774 doi "https://doi.org/10.1002/chem.201500127" @default.
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