FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091174168> ?p ?o ?g. }

• W2091174168 endingPage "4069" @default.
• W2091174168 startingPage "4059" @default.
• W2091174168 abstract "We studied whether the acute-phase protein alpha1-acid glycoprotein (AGP) induces rises in [Ca2+]i in neutrophils and sought to identify the corresponding AGP receptor (or receptors). We found that AGP elicited a minimal rise in [Ca2+]i in Fura-2-loaded neutrophils, and this response was markedly enhanced by pretreatment with anti-L-selectin antibodies. (The EC50 value of the AGP-induced Ca2+ response was 9 microg/ml.) Activation of phospholipase-C, Src tyrosine kinases, and PI3 kinases proved to be essential for the AGP-mediated increase in [Ca2+]i, whereas the p38 MAPK and SYK signaling pathways were not involved. Furthermore, antibodies against sialic acid binding, immunoglobulin-like lectin 5 (Siglec-5) and oligosaccharide 3'-sialyl-lactose both antagonized the AGP-induced response and caused an immediate increase in [Ca2+]i in anti-L-selectin-treated neutrophils, which indicates a signaling capacity of Siglec-5. We used modified forms of AGP (treated with mild periodate or neuraminidase) to establish the importance of sialic acid residues. The modified forms of AGP caused a much smaller rise in [Ca2+]i than did unaltered AGP. Affinity chromatography confirmed that unchanged AGP, but not neuraminidase-treated AGP, bound to Siglec-5. Our report provides the first evidence for a signaling capacity by AGP through a defined receptor. Pre-engagement of L-selectin significantly enhanced this signaling capacity." @default.
• W2091174168 created "2016-06-24" @default.
• W2091174168 creator A5009746135 @default.
• W2091174168 creator A5014934828 @default.
• W2091174168 creator A5053574502 @default.
• W2091174168 creator A5086919393 @default.
• W2091174168 date "2007-08-03" @default.
• W2091174168 modified "2023-09-23" @default.
• W2091174168 title "The acute‐phase protein α₁‐acid glycoprotein (AGP) induces rises in cytosolic Ca²⁺in neutrophil granulocytes<i>via</i>sialic acid binding immunoglobulin‐like lectins (Siglecs)" @default.
• W2091174168 cites W1487173514 @default.
• W2091174168 cites W1489043436 @default.
• W2091174168 cites W1507783048 @default.
• W2091174168 cites W1559556161 @default.
• W2091174168 cites W1582842326 @default.
• W2091174168 cites W1898554454 @default.
• W2091174168 cites W1917675481 @default.
• W2091174168 cites W1966930760 @default.
• W2091174168 cites W1967282700 @default.
• W2091174168 cites W1971776069 @default.
• W2091174168 cites W1987525830 @default.
• W2091174168 cites W2000536824 @default.
• W2091174168 cites W2001537808 @default.
• W2091174168 cites W2014185451 @default.
• W2091174168 cites W2017504214 @default.
• W2091174168 cites W2019530874 @default.
• W2091174168 cites W2028439746 @default.
• W2091174168 cites W2032366642 @default.
• W2091174168 cites W2036679771 @default.
• W2091174168 cites W2039145831 @default.
• W2091174168 cites W2047775965 @default.
• W2091174168 cites W2053305914 @default.
• W2091174168 cites W2059450339 @default.
• W2091174168 cites W2061440101 @default.
• W2091174168 cites W2066330621 @default.
• W2091174168 cites W2072901969 @default.
• W2091174168 cites W2077285790 @default.
• W2091174168 cites W2082706780 @default.
• W2091174168 cites W2083809698 @default.
• W2091174168 cites W2084754776 @default.
• W2091174168 cites W2107748719 @default.
• W2091174168 cites W2113094664 @default.
• W2091174168 cites W2127821227 @default.
• W2091174168 cites W2141260882 @default.
• W2091174168 cites W2146025254 @default.
• W2091174168 cites W2151777653 @default.
• W2091174168 cites W2152093499 @default.
• W2091174168 cites W2161661345 @default.
• W2091174168 cites W2162885959 @default.
• W2091174168 cites W2216247991 @default.
• W2091174168 cites W2415251987 @default.
• W2091174168 doi "https://doi.org/10.1096/fj.07-8534com" @default.
• W2091174168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17675532" @default.
• W2091174168 hasPublicationYear "2007" @default.
• W2091174168 type Work @default.
• W2091174168 sameAs 2091174168 @default.
• W2091174168 citedByCount "46" @default.
• W2091174168 countsByYear W20911741682012 @default.
• W2091174168 countsByYear W20911741682013 @default.
• W2091174168 countsByYear W20911741682014 @default.
• W2091174168 countsByYear W20911741682015 @default.
• W2091174168 countsByYear W20911741682016 @default.
• W2091174168 countsByYear W20911741682017 @default.
• W2091174168 countsByYear W20911741682019 @default.
• W2091174168 countsByYear W20911741682020 @default.
• W2091174168 countsByYear W20911741682021 @default.
• W2091174168 countsByYear W20911741682022 @default.
• W2091174168 countsByYear W20911741682023 @default.
• W2091174168 crossrefType "journal-article" @default.
• W2091174168 hasAuthorship W2091174168A5009746135 @default.
• W2091174168 hasAuthorship W2091174168A5014934828 @default.
• W2091174168 hasAuthorship W2091174168A5053574502 @default.
• W2091174168 hasAuthorship W2091174168A5086919393 @default.
• W2091174168 hasConcept C108625454 @default.
• W2091174168 hasConcept C134164806 @default.
• W2091174168 hasConcept C153911025 @default.
• W2091174168 hasConcept C159654299 @default.
• W2091174168 hasConcept C170493617 @default.
• W2091174168 hasConcept C181199279 @default.
• W2091174168 hasConcept C185592680 @default.
• W2091174168 hasConcept C203014093 @default.
• W2091174168 hasConcept C2777553839 @default.
• W2091174168 hasConcept C2779931124 @default.
• W2091174168 hasConcept C2780115458 @default.
• W2091174168 hasConcept C2780898057 @default.
• W2091174168 hasConcept C35174551 @default.
• W2091174168 hasConcept C42362537 @default.
• W2091174168 hasConcept C55493867 @default.
• W2091174168 hasConcept C86803240 @default.
• W2091174168 hasConceptScore W2091174168C108625454 @default.
• W2091174168 hasConceptScore W2091174168C134164806 @default.
• W2091174168 hasConceptScore W2091174168C153911025 @default.
• W2091174168 hasConceptScore W2091174168C159654299 @default.
• W2091174168 hasConceptScore W2091174168C170493617 @default.
• W2091174168 hasConceptScore W2091174168C181199279 @default.
• W2091174168 hasConceptScore W2091174168C185592680 @default.
• W2091174168 hasConceptScore W2091174168C203014093 @default.
• W2091174168 hasConceptScore W2091174168C2777553839 @default.
• W2091174168 hasConceptScore W2091174168C2779931124 @default.

• next