Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091180003> ?p ?o ?g. }
- W2091180003 endingPage "35510" @default.
- W2091180003 startingPage "35500" @default.
- W2091180003 abstract "Lithium is an effective mood stabilizer that has been clinically used to treat bipolar disorder for several decades. Recent studies have suggested that lithium possesses robust neuroprotective and anti-tumor properties. Thus far, a large number of lithium targets have been discovered. Here, we report for the first time that HDAC1 is a target of lithium. Lithium significantly down-regulated HDAC1 at the translational level by targeting HDAC1 mRNA. We also showed that depletion of HDAC1 is essential for the neuroprotective effects of lithium and for the lithium-mediated degradation of mutant huntingtin through the autophagic pathway. Our studies explain the multiple functions of lithium and reveal a novel mechanism for the function of lithium in neurodegeneration." @default.
- W2091180003 created "2016-06-24" @default.
- W2091180003 creator A5002274232 @default.
- W2091180003 creator A5010684653 @default.
- W2091180003 creator A5011124536 @default.
- W2091180003 creator A5012277463 @default.
- W2091180003 creator A5019862069 @default.
- W2091180003 creator A5020409706 @default.
- W2091180003 creator A5025929917 @default.
- W2091180003 creator A5034236037 @default.
- W2091180003 creator A5052618620 @default.
- W2091180003 creator A5052923310 @default.
- W2091180003 date "2013-12-01" @default.
- W2091180003 modified "2023-10-03" @default.
- W2091180003 title "Lithium Down-regulates Histone Deacetylase 1 (HDAC1) and Induces Degradation of Mutant Huntingtin" @default.
- W2091180003 cites W1546578130 @default.
- W2091180003 cites W1910848366 @default.
- W2091180003 cites W1964559779 @default.
- W2091180003 cites W1970254771 @default.
- W2091180003 cites W1971392223 @default.
- W2091180003 cites W1972149587 @default.
- W2091180003 cites W1972263121 @default.
- W2091180003 cites W1975307961 @default.
- W2091180003 cites W1978472558 @default.
- W2091180003 cites W1978664410 @default.
- W2091180003 cites W1979405589 @default.
- W2091180003 cites W1979993283 @default.
- W2091180003 cites W1982958012 @default.
- W2091180003 cites W1985124617 @default.
- W2091180003 cites W1987249631 @default.
- W2091180003 cites W1989133066 @default.
- W2091180003 cites W1990750894 @default.
- W2091180003 cites W1991224402 @default.
- W2091180003 cites W1993281728 @default.
- W2091180003 cites W1993643473 @default.
- W2091180003 cites W1994823455 @default.
- W2091180003 cites W1998707569 @default.
- W2091180003 cites W2004615717 @default.
- W2091180003 cites W2004980848 @default.
- W2091180003 cites W2008929289 @default.
- W2091180003 cites W2011094813 @default.
- W2091180003 cites W2013513647 @default.
- W2091180003 cites W2019699796 @default.
- W2091180003 cites W2019845642 @default.
- W2091180003 cites W2020797973 @default.
- W2091180003 cites W2022285476 @default.
- W2091180003 cites W2024413432 @default.
- W2091180003 cites W2025406984 @default.
- W2091180003 cites W2025596092 @default.
- W2091180003 cites W2032954363 @default.
- W2091180003 cites W2043882563 @default.
- W2091180003 cites W2045056620 @default.
- W2091180003 cites W2047415912 @default.
- W2091180003 cites W2056872519 @default.
- W2091180003 cites W2062887262 @default.
- W2091180003 cites W2063620211 @default.
- W2091180003 cites W2065247147 @default.
- W2091180003 cites W2069280713 @default.
- W2091180003 cites W2071570050 @default.
- W2091180003 cites W2084164174 @default.
- W2091180003 cites W2086853865 @default.
- W2091180003 cites W2087745495 @default.
- W2091180003 cites W2089545670 @default.
- W2091180003 cites W2093048712 @default.
- W2091180003 cites W2094935682 @default.
- W2091180003 cites W2098985594 @default.
- W2091180003 cites W2099803844 @default.
- W2091180003 cites W2103708669 @default.
- W2091180003 cites W2106012958 @default.
- W2091180003 cites W2106200048 @default.
- W2091180003 cites W2106227592 @default.
- W2091180003 cites W2109034822 @default.
- W2091180003 cites W2112136536 @default.
- W2091180003 cites W2112360818 @default.
- W2091180003 cites W2118827241 @default.
- W2091180003 cites W2121642311 @default.
- W2091180003 cites W2125904354 @default.
- W2091180003 cites W2127329372 @default.
- W2091180003 cites W2131347188 @default.
- W2091180003 cites W2131863923 @default.
- W2091180003 cites W2133809326 @default.
- W2091180003 cites W2136494061 @default.
- W2091180003 cites W2139425230 @default.
- W2091180003 cites W2153401206 @default.
- W2091180003 cites W2156320420 @default.
- W2091180003 cites W2158047249 @default.
- W2091180003 cites W2159561886 @default.
- W2091180003 cites W2159816895 @default.
- W2091180003 cites W2164367523 @default.
- W2091180003 cites W2165681578 @default.
- W2091180003 doi "https://doi.org/10.1074/jbc.m113.479865" @default.
- W2091180003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3853296" @default.
- W2091180003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24165128" @default.
- W2091180003 hasPublicationYear "2013" @default.
- W2091180003 type Work @default.
- W2091180003 sameAs 2091180003 @default.
- W2091180003 citedByCount "40" @default.
- W2091180003 countsByYear W20911800032014 @default.