FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091189056> ?p ?o ?g. }

• W2091189056 endingPage "1324" @default.
• W2091189056 startingPage "1309" @default.
• W2091189056 abstract "Laminin 5 regulates anchorage and motility of epithelial cells through integrins alpha6beta4 and alpha3beta1, respectively. We used targeted disruption of the LAMA3 gene, which encodes the alpha3 subunit of laminin 5 and other isoforms, to examine developmental functions that are regulated by adhesion to the basement membrane (BM). In homozygous null animals, profound epithelial abnormalities were detected that resulted in neonatal lethality, consistent with removal of all alpha3-laminin isoforms from epithelial BMs. Alterations in three different cellular functions were identified. First, using a novel tissue adhesion assay, we found that the mutant BM could not induce stable adhesion by integrin alpha6beta4, consistent with the presence of junctional blisters and abnormal hemidesmosomes. In the absence of laminin 5 function, we were able to detect a new ligand for integrin alpha3beta1 in the epidermal BM, suggesting that basal keratinocytes can utilize integrin alpha3beta1 to interact with an alternative ligand. Second, we identified a survival defect in mutant epithelial cells that could be rescued by exogenous laminin 5, collagen, or an antibody against integrin alpha6beta4, suggesting that signaling through beta1 or beta4 integrins is sufficient for survival. Third, we detected abnormalities in ameloblast differentiation in developing mutant incisors indicating that events downstream of adhesion are affected in mutant animals. These results indicate that laminin 5 has an important role in regulating tissue organization, gene expression, and survival of epithelium." @default.
• W2091189056 created "2016-06-24" @default.
• W2091189056 creator A5019483061 @default.
• W2091189056 creator A5048352998 @default.
• W2091189056 creator A5051338980 @default.
• W2091189056 creator A5068243605 @default.
• W2091189056 date "1999-06-14" @default.
• W2091189056 modified "2023-10-14" @default.
• W2091189056 title "Targeted Disruption of the <i>LAMA3</i> Gene in Mice Reveals Abnormalities in Survival and Late Stage Differentiation of Epithelial Cells" @default.
• W2091189056 cites W1496915816 @default.
• W2091189056 cites W1552753876 @default.
• W2091189056 cites W1595882330 @default.
• W2091189056 cites W1639755981 @default.
• W2091189056 cites W1839350769 @default.
• W2091189056 cites W1895730431 @default.
• W2091189056 cites W1971678284 @default.
• W2091189056 cites W1974599466 @default.
• W2091189056 cites W1976007544 @default.
• W2091189056 cites W1976010141 @default.
• W2091189056 cites W1981012480 @default.
• W2091189056 cites W1982387497 @default.
• W2091189056 cites W1985333314 @default.
• W2091189056 cites W1985848626 @default.
• W2091189056 cites W1992145299 @default.
• W2091189056 cites W1996059365 @default.
• W2091189056 cites W2000170431 @default.
• W2091189056 cites W2001493281 @default.
• W2091189056 cites W2002453151 @default.
• W2091189056 cites W2002787037 @default.
• W2091189056 cites W2006518478 @default.
• W2091189056 cites W2020134334 @default.
• W2091189056 cites W2022356114 @default.
• W2091189056 cites W2027745468 @default.
• W2091189056 cites W2030338830 @default.
• W2091189056 cites W2041400374 @default.
• W2091189056 cites W2041429746 @default.
• W2091189056 cites W2048845152 @default.
• W2091189056 cites W2052264968 @default.
• W2091189056 cites W2054298231 @default.
• W2091189056 cites W2055377343 @default.
• W2091189056 cites W2063385900 @default.
• W2091189056 cites W2070053893 @default.
• W2091189056 cites W2072041699 @default.
• W2091189056 cites W2075965099 @default.
• W2091189056 cites W2076166690 @default.
• W2091189056 cites W2080327002 @default.
• W2091189056 cites W2084628519 @default.
• W2091189056 cites W2086155215 @default.
• W2091189056 cites W2093343463 @default.
• W2091189056 cites W2106476914 @default.
• W2091189056 cites W2111430763 @default.
• W2091189056 cites W2111909780 @default.
• W2091189056 cites W2117250276 @default.
• W2091189056 cites W2119734833 @default.
• W2091189056 cites W2127791872 @default.
• W2091189056 cites W2137949057 @default.
• W2091189056 cites W2138316626 @default.
• W2091189056 cites W2142728962 @default.
• W2091189056 cites W2142942121 @default.
• W2091189056 cites W2143987989 @default.
• W2091189056 cites W2144026996 @default.
• W2091189056 cites W2145911955 @default.
• W2091189056 cites W2146989892 @default.
• W2091189056 cites W2149771795 @default.
• W2091189056 cites W2154000442 @default.
• W2091189056 cites W2168058510 @default.
• W2091189056 cites W2168946040 @default.
• W2091189056 cites W2198180938 @default.
• W2091189056 cites W2216072014 @default.
• W2091189056 cites W2269735591 @default.
• W2091189056 cites W2407838192 @default.
• W2091189056 doi "https://doi.org/10.1083/jcb.145.6.1309" @default.
• W2091189056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2133157" @default.
• W2091189056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10366601" @default.
• W2091189056 hasPublicationYear "1999" @default.
• W2091189056 type Work @default.
• W2091189056 sameAs 2091189056 @default.
• W2091189056 citedByCount "283" @default.
• W2091189056 countsByYear W20911890562012 @default.
• W2091189056 countsByYear W20911890562013 @default.
• W2091189056 countsByYear W20911890562014 @default.
• W2091189056 countsByYear W20911890562015 @default.
• W2091189056 countsByYear W20911890562016 @default.
• W2091189056 countsByYear W20911890562017 @default.
• W2091189056 countsByYear W20911890562018 @default.
• W2091189056 countsByYear W20911890562019 @default.
• W2091189056 countsByYear W20911890562020 @default.
• W2091189056 countsByYear W20911890562021 @default.
• W2091189056 countsByYear W20911890562022 @default.
• W2091189056 countsByYear W20911890562023 @default.
• W2091189056 crossrefType "journal-article" @default.
• W2091189056 hasAuthorship W2091189056A5019483061 @default.
• W2091189056 hasAuthorship W2091189056A5048352998 @default.
• W2091189056 hasAuthorship W2091189056A5051338980 @default.
• W2091189056 hasAuthorship W2091189056A5068243605 @default.
• W2091189056 hasBestOaLocation W20911890561 @default.
• W2091189056 hasConcept C104317684 @default.
• W2091189056 hasConcept C143065580 @default.

• next