FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091207754> ?p ?o ?g. }

• W2091207754 endingPage "121" @default.
• W2091207754 startingPage "115" @default.
• W2091207754 abstract "The pronociceptive effects of adenosine 5′-triphosphate (ATP) were examined in the low concentration formalin model (0.5%) by coadministration of ATP, ATP analogs (α,β-methylene-ATP and 2-methylthio-ATP) and antagonists (suramin, pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid) with formalin and determining effects on the expression of flinching behaviours. Coadministration of ATP (5–500 nmol) with formalin enhanced phase 2 (12–60 min after injection) but not phase 1 (0–10 min after injection) responses. α,β-methylene-ATP (0.5–50 nmol) but not 2-methylthio-ATP (50–500 nmol) produced a similar enhancement of activity, generating an order of potency of α,β-methylene-ATP, ATP≫2-methylthio-ATP. This enhancement was primarily expressed in the latter part of phase 2, 30–60 min after injection. Coadministration of suramin 50–500 nmol, a non-selective P2X and P2Y purinoceptor antagonist and pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid 5–500 nmol, a selective P2X purinoceptor antagonist, dose-dependently inhibited the augmentation of the formalin response by ATP 50 nmol, but did not reduce the response to formalin itself. Pretreatment for 30 min with higher doses of suramin inhibited the response to formalin (0.5%, 1.5%) and this appeared to be by a systemically mediated action as it was seen following administration into the contralateral paw. The results of this study provide evidence in support of a P2X purinoceptor mediated augmentation of the pain signal by ATP. The delayed time-course of the effect suggests that it may occur in concert with other mediators that are recruited by the inflammatory process, rather than reflecting a direct depolarization of sensory nerves. Other behavioural paradigms may be required to examine the fast onset, direct effect. Suramin appears to exert both local and systemic effects on the expression of pain behaviours in response to formalin." @default.
• W2091207754 created "2016-06-24" @default.
• W2091207754 creator A5012815771 @default.
• W2091207754 creator A5081454540 @default.
• W2091207754 date "1997-07-01" @default.
• W2091207754 modified "2023-10-18" @default.
• W2091207754 title "Peripheral adenosine 5′-triphosphate enhances nociception in the formalin test via activation of a purinergic p2X receptor" @default.
• W2091207754 cites W1815757713 @default.
• W2091207754 cites W1958508359 @default.
• W2091207754 cites W1964916798 @default.
• W2091207754 cites W1965113135 @default.
• W2091207754 cites W1979152924 @default.
• W2091207754 cites W1982422046 @default.
• W2091207754 cites W1986552791 @default.
• W2091207754 cites W1988847736 @default.
• W2091207754 cites W1996165890 @default.
• W2091207754 cites W2002434680 @default.
• W2091207754 cites W2003364993 @default.
• W2091207754 cites W2009345240 @default.
• W2091207754 cites W2014683303 @default.
• W2091207754 cites W2019338582 @default.
• W2091207754 cites W2021980620 @default.
• W2091207754 cites W2025225223 @default.
• W2091207754 cites W2043847401 @default.
• W2091207754 cites W2044188934 @default.
• W2091207754 cites W2044686423 @default.
• W2091207754 cites W2045332499 @default.
• W2091207754 cites W2048135877 @default.
• W2091207754 cites W2048201868 @default.
• W2091207754 cites W2049261807 @default.
• W2091207754 cites W2050338155 @default.
• W2091207754 cites W2050907429 @default.
• W2091207754 cites W2054615749 @default.
• W2091207754 cites W2070181766 @default.
• W2091207754 cites W2071184494 @default.
• W2091207754 cites W2079517872 @default.
• W2091207754 cites W2084701217 @default.
• W2091207754 cites W2091190709 @default.
• W2091207754 cites W2091752732 @default.
• W2091207754 cites W2093115947 @default.
• W2091207754 cites W2137739507 @default.
• W2091207754 cites W2151443047 @default.
• W2091207754 cites W2152216921 @default.
• W2091207754 doi "https://doi.org/10.1016/s0014-2999(97)01001-7" @default.
• W2091207754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9253943" @default.
• W2091207754 hasPublicationYear "1997" @default.
• W2091207754 type Work @default.
• W2091207754 sameAs 2091207754 @default.
• W2091207754 citedByCount "87" @default.
• W2091207754 countsByYear W20912077542013 @default.
• W2091207754 countsByYear W20912077542014 @default.
• W2091207754 countsByYear W20912077542015 @default.
• W2091207754 countsByYear W20912077542016 @default.
• W2091207754 countsByYear W20912077542020 @default.
• W2091207754 countsByYear W20912077542021 @default.
• W2091207754 countsByYear W20912077542022 @default.
• W2091207754 crossrefType "journal-article" @default.
• W2091207754 hasAuthorship W2091207754A5012815771 @default.
• W2091207754 hasAuthorship W2091207754A5081454540 @default.
• W2091207754 hasConcept C15490471 @default.
• W2091207754 hasConcept C170493617 @default.
• W2091207754 hasConcept C185592680 @default.
• W2091207754 hasConcept C202751555 @default.
• W2091207754 hasConcept C2776182878 @default.
• W2091207754 hasConcept C2776885963 @default.
• W2091207754 hasConcept C2776991684 @default.
• W2091207754 hasConcept C2779564974 @default.
• W2091207754 hasConcept C2780019924 @default.
• W2091207754 hasConcept C2780410667 @default.
• W2091207754 hasConcept C55493867 @default.
• W2091207754 hasConcept C57306754 @default.
• W2091207754 hasConcept C57992300 @default.
• W2091207754 hasConcept C71924100 @default.
• W2091207754 hasConcept C98274493 @default.
• W2091207754 hasConceptScore W2091207754C15490471 @default.
• W2091207754 hasConceptScore W2091207754C170493617 @default.
• W2091207754 hasConceptScore W2091207754C185592680 @default.
• W2091207754 hasConceptScore W2091207754C202751555 @default.
• W2091207754 hasConceptScore W2091207754C2776182878 @default.
• W2091207754 hasConceptScore W2091207754C2776885963 @default.
• W2091207754 hasConceptScore W2091207754C2776991684 @default.
• W2091207754 hasConceptScore W2091207754C2779564974 @default.
• W2091207754 hasConceptScore W2091207754C2780019924 @default.
• W2091207754 hasConceptScore W2091207754C2780410667 @default.
• W2091207754 hasConceptScore W2091207754C55493867 @default.
• W2091207754 hasConceptScore W2091207754C57306754 @default.
• W2091207754 hasConceptScore W2091207754C57992300 @default.
• W2091207754 hasConceptScore W2091207754C71924100 @default.
• W2091207754 hasConceptScore W2091207754C98274493 @default.
• W2091207754 hasIssue "2-3" @default.
• W2091207754 hasLocation W20912077541 @default.
• W2091207754 hasLocation W20912077542 @default.
• W2091207754 hasOpenAccess W2091207754 @default.
• W2091207754 hasPrimaryLocation W20912077541 @default.
• W2091207754 hasRelatedWork W1973899430 @default.
• W2091207754 hasRelatedWork W1992252859 @default.
• W2091207754 hasRelatedWork W2000937353 @default.
• W2091207754 hasRelatedWork W2052690399 @default.

• next