FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091208551> ?p ?o ?g. }

• W2091208551 endingPage "1141" @default.
• W2091208551 startingPage "1135" @default.
• W2091208551 abstract "Background The impact of HLA-specific antibodies is not well established in the acute rejection of lung allografts. Acute rejection represents the most important risk factor for the development of chronic lung allograft dysfunction. Methods We analyzed the pattern of HLA antibodies before and after transplantation in 54 patients, and correlated our data with the presence and frequency of high-grade and persistent-recurrent acute rejection, during the first 18 post-operative months. The diagnosis of acute rejection was based on histologic International Society for Heart and Lung Transplantation (ISHLT)-published criteria. Results Ten of 54 patients had a positive enzyme-linked immunoassay (ELISA) post-transplantation. In 90% of ELISA-positive patients, the presence of HLA antibodies was associated with persistent-recurrent acute rejections, compared with 34% in the ELISA-negative group (p < 0.005). There were 28 high-grade acute rejection episodes in the ELISA-positive group, compared with 36 in the ELISA-negative group (p < 0.0001). The ELISA-positive patients required a greater intensity of immunosuppressive therapy. The patients with ELISA-detected anti-HLA antibodies were at least 3-fold more likely to develop high-grade acute rejection and persistent-recurrent acute rejection, and 7-fold more likely to develop multiple episodes of persistent-recurrent acute rejection, compared with ELISA-negative patients. Conclusions ELISA-based screening for the development of HLA antibodies is a reliable method that can identify lung transplant recipients at increased risk for high-grade and persistent-recurrent acute rejection. Although bronchiolitis obliterans appears as a point of no return in the evolution of lung-transplanted patients, early detection of risk factors for acute rejection could indirectly decrease the incidence of bronchiolitis obliterans. These lung-transplanted patients may benefit from an altered strategy of immunosuppression." @default.
• W2091208551 created "2016-06-24" @default.
• W2091208551 creator A5000549821 @default.
• W2091208551 creator A5002906339 @default.
• W2091208551 creator A5010150963 @default.
• W2091208551 creator A5034482742 @default.
• W2091208551 creator A5058363405 @default.
• W2091208551 creator A5058858595 @default.
• W2091208551 creator A5062605476 @default.
• W2091208551 creator A5070818318 @default.
• W2091208551 creator A5079977674 @default.
• W2091208551 creator A5084038963 @default.
• W2091208551 creator A5087293366 @default.
• W2091208551 creator A5087572312 @default.
• W2091208551 date "2004-10-01" @default.
• W2091208551 modified "2023-09-27" @default.
• W2091208551 title "HLA-Specific antibodies are associated with high-grade and persistent-recurrent lung allograft acute rejection" @default.
• W2091208551 cites W1411210768 @default.
• W2091208551 cites W1963928756 @default.
• W2091208551 cites W1980073060 @default.
• W2091208551 cites W2018592991 @default.
• W2091208551 cites W2024004493 @default.
• W2091208551 cites W2033154340 @default.
• W2091208551 cites W2046578161 @default.
• W2091208551 cites W2066667006 @default.
• W2091208551 cites W2070153910 @default.
• W2091208551 cites W2082140737 @default.
• W2091208551 cites W2084263703 @default.
• W2091208551 cites W2088810713 @default.
• W2091208551 cites W2090422204 @default.
• W2091208551 cites W2105949004 @default.
• W2091208551 cites W2112408403 @default.
• W2091208551 cites W2126010472 @default.
• W2091208551 cites W2126965885 @default.
• W2091208551 cites W2129241145 @default.
• W2091208551 cites W2136040035 @default.
• W2091208551 cites W2137331999 @default.
• W2091208551 cites W2144391693 @default.
• W2091208551 cites W2153280279 @default.
• W2091208551 doi "https://doi.org/10.1016/j.healun.2003.08.030" @default.
• W2091208551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15477106" @default.
• W2091208551 hasPublicationYear "2004" @default.
• W2091208551 type Work @default.
• W2091208551 sameAs 2091208551 @default.
• W2091208551 citedByCount "127" @default.
• W2091208551 countsByYear W20912085512012 @default.
• W2091208551 countsByYear W20912085512013 @default.
• W2091208551 countsByYear W20912085512014 @default.
• W2091208551 countsByYear W20912085512015 @default.
• W2091208551 countsByYear W20912085512016 @default.
• W2091208551 countsByYear W20912085512017 @default.
• W2091208551 countsByYear W20912085512018 @default.
• W2091208551 countsByYear W20912085512019 @default.
• W2091208551 countsByYear W20912085512020 @default.
• W2091208551 countsByYear W20912085512021 @default.
• W2091208551 countsByYear W20912085512022 @default.
• W2091208551 countsByYear W20912085512023 @default.
• W2091208551 crossrefType "journal-article" @default.
• W2091208551 hasAuthorship W2091208551A5000549821 @default.
• W2091208551 hasAuthorship W2091208551A5002906339 @default.
• W2091208551 hasAuthorship W2091208551A5010150963 @default.
• W2091208551 hasAuthorship W2091208551A5034482742 @default.
• W2091208551 hasAuthorship W2091208551A5058363405 @default.
• W2091208551 hasAuthorship W2091208551A5058858595 @default.
• W2091208551 hasAuthorship W2091208551A5062605476 @default.
• W2091208551 hasAuthorship W2091208551A5070818318 @default.
• W2091208551 hasAuthorship W2091208551A5079977674 @default.
• W2091208551 hasAuthorship W2091208551A5084038963 @default.
• W2091208551 hasAuthorship W2091208551A5087293366 @default.
• W2091208551 hasAuthorship W2091208551A5087572312 @default.
• W2091208551 hasConcept C126322002 @default.
• W2091208551 hasConcept C147483822 @default.
• W2091208551 hasConcept C159654299 @default.
• W2091208551 hasConcept C188280979 @default.
• W2091208551 hasConcept C203014093 @default.
• W2091208551 hasConcept C2776739411 @default.
• W2091208551 hasConcept C2777714996 @default.
• W2091208551 hasConcept C2781448352 @default.
• W2091208551 hasConcept C2911091166 @default.
• W2091208551 hasConcept C71924100 @default.
• W2091208551 hasConcept C90924648 @default.
• W2091208551 hasConceptScore W2091208551C126322002 @default.
• W2091208551 hasConceptScore W2091208551C147483822 @default.
• W2091208551 hasConceptScore W2091208551C159654299 @default.
• W2091208551 hasConceptScore W2091208551C188280979 @default.
• W2091208551 hasConceptScore W2091208551C203014093 @default.
• W2091208551 hasConceptScore W2091208551C2776739411 @default.
• W2091208551 hasConceptScore W2091208551C2777714996 @default.
• W2091208551 hasConceptScore W2091208551C2781448352 @default.
• W2091208551 hasConceptScore W2091208551C2911091166 @default.
• W2091208551 hasConceptScore W2091208551C71924100 @default.
• W2091208551 hasConceptScore W2091208551C90924648 @default.
• W2091208551 hasIssue "10" @default.
• W2091208551 hasLocation W20912085511 @default.
• W2091208551 hasLocation W20912085512 @default.
• W2091208551 hasOpenAccess W2091208551 @default.
• W2091208551 hasPrimaryLocation W20912085511 @default.
• W2091208551 hasRelatedWork W1966155747 @default.

• next