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- W2091209259 abstract "The cumulative exposure to estrogens is an important determinant in the risk of breast cancer, yet the full range of mechanisms involving estrogens in the genesis and progression of breast cancer remains a subject of debate. Interactions of estrogens and environmental toxicants have received attention as putative factors contributing to carcinogenesis. Mechanistic studies have demonstrated interactions between estrogen receptor α (ERα) and the aryl hydrocarbon receptor (AhR), with consequences on the genes that they regulate. Many studies of ERα and AhR-mediated effects and crosstalk between them have focused on the initial molecular events. In this study, we investigated ERα- and AhR-mediated effects in long-term estrogen exposed (LTEE) MCF-7 human breast cancer cells, which were obtained by continuous culturing for at least 12 weeks in medium supplemented with 1 nM of 17β-estradiol (E2). With these LTEE cells and with parallel control cells cultured without E2 supplementation, we performed an extensive study of cytochrome P450 (CYP) induction, carcinogen bioactivation, global gene expression, and tumorigenicity in immunocompromised mice. We found that LTEE cells, in comparison with control cells, had higher levels of AhR mRNA and protein, greater responsiveness for AhR-regulated CYP1A1 and CYP1B1 induction, a 6-fold higher initial level of benzo(a)pyrene-DNA adducts as determined by liquid chromatography tandem mass spectrometry, marked differences in the expression of numerous genes, and a higher rate of E2-dependent tumor growth as xenografts. These studies indicate that LTEE causes adaptive responses in MCF-7 cells, which may reflect processes that contribute to the overall carcinogenic effect of E2." @default.
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- W2091209259 date "2009-11-01" @default.
- W2091209259 modified "2023-10-11" @default.
- W2091209259 title "Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells" @default.
- W2091209259 cites W1507384014 @default.
- W2091209259 cites W1516590629 @default.
- W2091209259 cites W1573746641 @default.
- W2091209259 cites W1955002699 @default.
- W2091209259 cites W1966598308 @default.
- W2091209259 cites W1969490406 @default.
- W2091209259 cites W1971772902 @default.
- W2091209259 cites W1976629038 @default.
- W2091209259 cites W1980027440 @default.
- W2091209259 cites W1984320840 @default.
- W2091209259 cites W1984926660 @default.
- W2091209259 cites W1986801952 @default.
- W2091209259 cites W1988399164 @default.
- W2091209259 cites W1989137568 @default.
- W2091209259 cites W1992836428 @default.
- W2091209259 cites W1994853124 @default.
- W2091209259 cites W1996079450 @default.
- W2091209259 cites W1997341599 @default.
- W2091209259 cites W2000266564 @default.
- W2091209259 cites W2006140635 @default.
- W2091209259 cites W2007405028 @default.
- W2091209259 cites W2007405710 @default.
- W2091209259 cites W2009360495 @default.
- W2091209259 cites W2021239799 @default.
- W2091209259 cites W2024477210 @default.
- W2091209259 cites W2024606555 @default.
- W2091209259 cites W2028691872 @default.
- W2091209259 cites W2031797332 @default.
- W2091209259 cites W2031832827 @default.
- W2091209259 cites W2031909185 @default.
- W2091209259 cites W2033577716 @default.
- W2091209259 cites W2036453168 @default.
- W2091209259 cites W2036510337 @default.
- W2091209259 cites W2036531864 @default.
- W2091209259 cites W2043278640 @default.
- W2091209259 cites W2046824948 @default.
- W2091209259 cites W2050401007 @default.
- W2091209259 cites W2050572437 @default.
- W2091209259 cites W2053429233 @default.
- W2091209259 cites W2053978494 @default.
- W2091209259 cites W2062354480 @default.
- W2091209259 cites W2063313240 @default.
- W2091209259 cites W2066063870 @default.
- W2091209259 cites W2071728131 @default.
- W2091209259 cites W2072828753 @default.
- W2091209259 cites W2075158731 @default.
- W2091209259 cites W2076676413 @default.
- W2091209259 cites W2080647760 @default.
- W2091209259 cites W2095628944 @default.
- W2091209259 cites W2098440278 @default.
- W2091209259 cites W2098999466 @default.
- W2091209259 cites W2107859602 @default.
- W2091209259 cites W2109541969 @default.
- W2091209259 cites W2111225227 @default.
- W2091209259 cites W2112025328 @default.
- W2091209259 cites W2117520145 @default.
- W2091209259 cites W2118530235 @default.
- W2091209259 cites W2121071871 @default.
- W2091209259 cites W2121472554 @default.
- W2091209259 cites W2122040419 @default.
- W2091209259 cites W2129175864 @default.
- W2091209259 cites W2131989143 @default.
- W2091209259 cites W2132451509 @default.
- W2091209259 cites W2132945004 @default.
- W2091209259 cites W2136919926 @default.
- W2091209259 cites W2139727090 @default.
- W2091209259 cites W2142739119 @default.
- W2091209259 cites W2151187507 @default.
- W2091209259 cites W2161966331 @default.
- W2091209259 cites W2165055517 @default.
- W2091209259 cites W2165422066 @default.
- W2091209259 cites W2166969772 @default.
- W2091209259 cites W2169110289 @default.
- W2091209259 cites W2313869316 @default.
- W2091209259 cites W4232031691 @default.
- W2091209259 cites W4238448376 @default.
- W2091209259 cites W4240237951 @default.
- W2091209259 cites W4243535341 @default.
- W2091209259 doi "https://doi.org/10.1016/j.taap.2009.07.013" @default.
- W2091209259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3180932" @default.
- W2091209259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19619570" @default.
- W2091209259 hasPublicationYear "2009" @default.
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