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- W2091210975 abstract "During a Lise-Meitner-Program research project, bioassay-guided fractionation of species belonging to Clusiaceae (Mammey Apple Family) was conducted to isolate new bioactive substances. Several species of Hypericum L. (St. John's Wort) have records of traditional use in topical applications for reducing inflammation and wound-healing [1]. Therefore, lipophilic extracts of 9 species of Hypericum (all belonging to tribe Hypericeae) were examined. In addition, lipophilic extracts from Triadenum walterii (tribe Hypericeae) and Clusia valerioi (tribe Clusieae) were studied. Results of anti-inflammatory bioassays for several isolated compounds against COX-1, COX-2, and 5-LOX, enzymes implicated in inflammation response, indicated that a new phloroglucinol derivative (1) from H. lissophloeus had the highest activity against COX-1 (IC50 9.5 uM) and a known xanthone (2) and phloroglucinol derivative (3) from H. canariense displayed the highest activity against COX-2 (IC50 16.9 uM) and 5-LOX (IC50 0.3 uM), respectively." @default.
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- W2091210975 date "2007-01-01" @default.
- W2091210975 modified "2023-09-25" @default.
- W2091210975 title "Anti-inflammatory Phloroglucinol and Terpenoid Derivatives from Clusiaceae" @default.
- W2091210975 doi "https://doi.org/10.1055/s-2007-986851" @default.
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