FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091211010> ?p ?o ?g. }

• W2091211010 endingPage "383" @default.
• W2091211010 startingPage "375" @default.
• W2091211010 abstract "The large (L) protein of Sendai virus complexes with the phosphoprotein (P) to form the active RNA-dependent RNA polymerase. The L protein is believed to be responsible for all of the catalytic activities of the polymerase associated with transcription and replication. Sequence alignment of the L proteins of negative-strand RNA viruses has revealed six conserved domains (I–VI) thought to be responsible for the enzymatic activities. Charged-to-alanine mutagenesis was carried out in a highly charged, conserved region (amino acids 533–569) within domain II to test the hypothesis of Müller et al. [ J. Gen. Virol. 75, 1345–1352 (1994)] that this region may contribute to the template binding domain of the viral RNA polymerase. The mutant proteins were tested for expression and stability, the ability to synthesize viral RNA in vitro and in vivo , and protein–protein interactions. Five of the seven mutants were completely defective in all viral RNA synthesis, whereas two mutants showed significant levels of both mRNA and leader RNA synthesis. One of the transcriptionally active mutants also gave genome replication in vitro although not in vivo . The other mutant was defective in all the replication assays and thus the mutation uncoupled transcription and replication. Because the completely inactive L mutants can bind to the P protein to form the polymerase complex and the polymerases bind to the viral nucleocapsid template, these amino acids are essential for the activity of the L protein." @default.
• W2091211010 created "2016-06-24" @default.
• W2091211010 creator A5022864711 @default.
• W2091211010 creator A5029203160 @default.
• W2091211010 creator A5030470945 @default.
• W2091211010 creator A5073903972 @default.
• W2091211010 creator A5090561334 @default.
• W2091211010 date "1999-09-01" @default.
• W2091211010 modified "2023-09-30" @default.
• W2091211010 title "Mutations in Conserved Domain II of the Large (L) Subunit of the Sendai Virus RNA Polymerase Abolish RNA Synthesis" @default.
• W2091211010 cites W1483177484 @default.
• W2091211010 cites W1559602870 @default.
• W2091211010 cites W1565531062 @default.
• W2091211010 cites W1573113880 @default.
• W2091211010 cites W1605220975 @default.
• W2091211010 cites W1613935160 @default.
• W2091211010 cites W1669527819 @default.
• W2091211010 cites W1762168883 @default.
• W2091211010 cites W1775741884 @default.
• W2091211010 cites W1779806393 @default.
• W2091211010 cites W1920130372 @default.
• W2091211010 cites W1950992607 @default.
• W2091211010 cites W1983286380 @default.
• W2091211010 cites W1992252124 @default.
• W2091211010 cites W1993772444 @default.
• W2091211010 cites W2005411001 @default.
• W2091211010 cites W2008954911 @default.
• W2091211010 cites W2009581957 @default.
• W2091211010 cites W2012288971 @default.
• W2091211010 cites W2038351251 @default.
• W2091211010 cites W2043819317 @default.
• W2091211010 cites W2047996719 @default.
• W2091211010 cites W2049852794 @default.
• W2091211010 cites W2054917840 @default.
• W2091211010 cites W2066297924 @default.
• W2091211010 cites W2088533278 @default.
• W2091211010 cites W2106835078 @default.
• W2091211010 cites W2122045154 @default.
• W2091211010 cites W2127026326 @default.
• W2091211010 cites W2142714926 @default.
• W2091211010 cites W2166783177 @default.
• W2091211010 cites W2168423500 @default.
• W2091211010 cites W22781165 @default.
• W2091211010 doi "https://doi.org/10.1006/viro.1999.9933" @default.
• W2091211010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10502516" @default.
• W2091211010 hasPublicationYear "1999" @default.
• W2091211010 type Work @default.
• W2091211010 sameAs 2091211010 @default.
• W2091211010 citedByCount "46" @default.
• W2091211010 countsByYear W20912110102012 @default.
• W2091211010 countsByYear W20912110102013 @default.
• W2091211010 countsByYear W20912110102015 @default.
• W2091211010 countsByYear W20912110102016 @default.
• W2091211010 countsByYear W20912110102017 @default.
• W2091211010 countsByYear W20912110102019 @default.
• W2091211010 crossrefType "journal-article" @default.
• W2091211010 hasAuthorship W2091211010A5022864711 @default.
• W2091211010 hasAuthorship W2091211010A5029203160 @default.
• W2091211010 hasAuthorship W2091211010A5030470945 @default.
• W2091211010 hasAuthorship W2091211010A5073903972 @default.
• W2091211010 hasAuthorship W2091211010A5090561334 @default.
• W2091211010 hasBestOaLocation W20912110101 @default.
• W2091211010 hasConcept C101762097 @default.
• W2091211010 hasConcept C104317684 @default.
• W2091211010 hasConcept C138885662 @default.
• W2091211010 hasConcept C140704245 @default.
• W2091211010 hasConcept C150194340 @default.
• W2091211010 hasConcept C153911025 @default.
• W2091211010 hasConcept C159047783 @default.
• W2091211010 hasConcept C179926584 @default.
• W2091211010 hasConcept C21786251 @default.
• W2091211010 hasConcept C2522874641 @default.
• W2091211010 hasConcept C25281209 @default.
• W2091211010 hasConcept C2776449523 @default.
• W2091211010 hasConcept C2780127873 @default.
• W2091211010 hasConcept C41258723 @default.
• W2091211010 hasConcept C41895202 @default.
• W2091211010 hasConcept C552990157 @default.
• W2091211010 hasConcept C55493867 @default.
• W2091211010 hasConcept C64350747 @default.
• W2091211010 hasConcept C67705224 @default.
• W2091211010 hasConcept C82381507 @default.
• W2091211010 hasConcept C86803240 @default.
• W2091211010 hasConceptScore W2091211010C101762097 @default.
• W2091211010 hasConceptScore W2091211010C104317684 @default.
• W2091211010 hasConceptScore W2091211010C138885662 @default.
• W2091211010 hasConceptScore W2091211010C140704245 @default.
• W2091211010 hasConceptScore W2091211010C150194340 @default.
• W2091211010 hasConceptScore W2091211010C153911025 @default.
• W2091211010 hasConceptScore W2091211010C159047783 @default.
• W2091211010 hasConceptScore W2091211010C179926584 @default.
• W2091211010 hasConceptScore W2091211010C21786251 @default.
• W2091211010 hasConceptScore W2091211010C2522874641 @default.
• W2091211010 hasConceptScore W2091211010C25281209 @default.
• W2091211010 hasConceptScore W2091211010C2776449523 @default.
• W2091211010 hasConceptScore W2091211010C2780127873 @default.
• W2091211010 hasConceptScore W2091211010C41258723 @default.
• W2091211010 hasConceptScore W2091211010C41895202 @default.

• next