FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091212816> ?p ?o ?g. }

• W2091212816 endingPage "118" @default.
• W2091212816 startingPage "111" @default.
• W2091212816 abstract "The goal of this study was to characterize the mechanism by which hyperprolactinemia alters testosterone production in rat testicular interstitial cells (TICs). Hyperprolactinemia was induced by grafting 2 anterior pituitary (AP) glands under the subcapsular space of the kidney in experimental rats. Control rats were grafted with brain cortex (CX). Six weeks post-grafting, rats were challenged with human chorionic gonadotropin (hCG) then, the changes in either plasma testosterone or luteinizing hormone was measured. Additionally, TICs were isolated and challenged in vitro with hCG or prolactin, and the testosterone release measured by radioimmunoassay. Further investigation in signal transduction as intracellular 3′:5′ cyclic adenosine monophosphate (cAMP) production was observed under a regulation of forskolin or SQ22536. After the challenge of hCG or GnRH, the AP-grafted rats showed a suppressed response in testosterone release as compared to those in the CX-grafted group. The in vitro data from the AP-grafted rats compared to the CX-grafted animals showed a diminished response in testosterone release upon hCG stimulation. Administration of forskolin or SQ22536 disclosed dysfunction of adenylate cyclase in TICs from the AP-grafted rats. When 8-Br-cAMP was incubated with TICs, the testosterone production was lower in the AP-grafted compared to the CX-grafted group. These results suggest that in addition to adenylate cyclase dysfunction, inefficiency of post-cAMP pathways are also involved in the hypogonadism elicited by hyperprolactinemia in rats. J. Cell. Biochem. 74:111–118, 1999. © 1999 Wiley-Liss, Inc." @default.
• W2091212816 created "2016-06-24" @default.
• W2091212816 creator A5005494237 @default.
• W2091212816 creator A5008488401 @default.
• W2091212816 creator A5009868732 @default.
• W2091212816 creator A5025595895 @default.
• W2091212816 creator A5026727584 @default.
• W2091212816 creator A5032170703 @default.
• W2091212816 creator A5050104295 @default.
• W2091212816 creator A5062880857 @default.
• W2091212816 creator A5075672011 @default.
• W2091212816 creator A5089136380 @default.
• W2091212816 creator A5090274582 @default.
• W2091212816 date "1999-07-01" @default.
• W2091212816 modified "2023-10-11" @default.
• W2091212816 title "Regulation of testosterone secretion by prolactin in male rats" @default.
• W2091212816 cites W1911768729 @default.
• W2091212816 cites W1965217754 @default.
• W2091212816 cites W1969849800 @default.
• W2091212816 cites W1985325011 @default.
• W2091212816 cites W1986899664 @default.
• W2091212816 cites W1987063029 @default.
• W2091212816 cites W1988966475 @default.
• W2091212816 cites W1999765042 @default.
• W2091212816 cites W2015217559 @default.
• W2091212816 cites W2018249696 @default.
• W2091212816 cites W2020931685 @default.
• W2091212816 cites W2022249912 @default.
• W2091212816 cites W2022350411 @default.
• W2091212816 cites W2034958855 @default.
• W2091212816 cites W2042879617 @default.
• W2091212816 cites W2051525392 @default.
• W2091212816 cites W2051794913 @default.
• W2091212816 cites W2083227795 @default.
• W2091212816 cites W2088828363 @default.
• W2091212816 cites W2090574273 @default.
• W2091212816 cites W2100508933 @default.
• W2091212816 cites W2115469688 @default.
• W2091212816 cites W2135676919 @default.
• W2091212816 cites W2162581532 @default.
• W2091212816 cites W2164067550 @default.
• W2091212816 cites W2414363519 @default.
• W2091212816 cites W2062447030 @default.
• W2091212816 doi "https://doi.org/10.1002/(sici)1097-4644(19990701)74:1<111::aid-jcb12>3.0.co;2-i" @default.
• W2091212816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10381267" @default.
• W2091212816 hasPublicationYear "1999" @default.
• W2091212816 type Work @default.
• W2091212816 sameAs 2091212816 @default.
• W2091212816 citedByCount "22" @default.
• W2091212816 countsByYear W20912128162012 @default.
• W2091212816 countsByYear W20912128162015 @default.
• W2091212816 countsByYear W20912128162016 @default.
• W2091212816 countsByYear W20912128162017 @default.
• W2091212816 countsByYear W20912128162021 @default.
• W2091212816 crossrefType "journal-article" @default.
• W2091212816 hasAuthorship W2091212816A5005494237 @default.
• W2091212816 hasAuthorship W2091212816A5008488401 @default.
• W2091212816 hasAuthorship W2091212816A5009868732 @default.
• W2091212816 hasAuthorship W2091212816A5025595895 @default.
• W2091212816 hasAuthorship W2091212816A5026727584 @default.
• W2091212816 hasAuthorship W2091212816A5032170703 @default.
• W2091212816 hasAuthorship W2091212816A5050104295 @default.
• W2091212816 hasAuthorship W2091212816A5062880857 @default.
• W2091212816 hasAuthorship W2091212816A5075672011 @default.
• W2091212816 hasAuthorship W2091212816A5089136380 @default.
• W2091212816 hasAuthorship W2091212816A5090274582 @default.
• W2091212816 hasConcept C126322002 @default.
• W2091212816 hasConcept C134018914 @default.
• W2091212816 hasConcept C170493617 @default.
• W2091212816 hasConcept C176685330 @default.
• W2091212816 hasConcept C180526460 @default.
• W2091212816 hasConcept C185592680 @default.
• W2091212816 hasConcept C24998067 @default.
• W2091212816 hasConcept C2775948956 @default.
• W2091212816 hasConcept C2776668983 @default.
• W2091212816 hasConcept C2778575703 @default.
• W2091212816 hasConcept C2779064019 @default.
• W2091212816 hasConcept C2779276759 @default.
• W2091212816 hasConcept C2779279991 @default.
• W2091212816 hasConcept C71315377 @default.
• W2091212816 hasConcept C71924100 @default.
• W2091212816 hasConcept C86803240 @default.
• W2091212816 hasConceptScore W2091212816C126322002 @default.
• W2091212816 hasConceptScore W2091212816C134018914 @default.
• W2091212816 hasConceptScore W2091212816C170493617 @default.
• W2091212816 hasConceptScore W2091212816C176685330 @default.
• W2091212816 hasConceptScore W2091212816C180526460 @default.
• W2091212816 hasConceptScore W2091212816C185592680 @default.
• W2091212816 hasConceptScore W2091212816C24998067 @default.
• W2091212816 hasConceptScore W2091212816C2775948956 @default.
• W2091212816 hasConceptScore W2091212816C2776668983 @default.
• W2091212816 hasConceptScore W2091212816C2778575703 @default.
• W2091212816 hasConceptScore W2091212816C2779064019 @default.
• W2091212816 hasConceptScore W2091212816C2779276759 @default.
• W2091212816 hasConceptScore W2091212816C2779279991 @default.
• W2091212816 hasConceptScore W2091212816C71315377 @default.
• W2091212816 hasConceptScore W2091212816C71924100 @default.
• W2091212816 hasConceptScore W2091212816C86803240 @default.

• next