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- W2091213817 abstract "Diffuse large B cell lymphomas (DLBCL) derive from germinal center (GC) B cells and display chromosomal alterations deregulating the expression of BCL6, a transcriptional repressor required for GC formation. To investigate the role of BCL6 in DLBCL pathogenesis, we have engineered mice that express BCL6 constitutively in B cells by mimicking a chromosomal translocation found in human DLBCL. These mice display increased GC formation and perturbed post-GC differentiation characterized by a decreased number of post-isotype switch plasma cells. Subsequently, these mice develop a lymphoproliferative syndrome that culminates with the development of lymphomas displaying features typical of human DLBCL. These results define the oncogenic role of BCL6 in the pathogenesis of DLBCL and provide a faithful mouse model of this common disease." @default.
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- W2091213817 date "2005-05-01" @default.
- W2091213817 modified "2023-10-18" @default.
- W2091213817 title "Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice" @default.
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- W2091213817 doi "https://doi.org/10.1016/j.ccr.2005.03.037" @default.
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