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• W2091215457 abstract "Asymmetric positioning of proteins within cells is crucial for cell polarization and function. Deployment of Oskar protein at the posterior pole of the Drosophila oocyte relies on localization of the oskar mRNA, repression of its translation prior to localization, and finally activation of translation. Translational repression is mediated by BREs, regulatory elements positioned in two clusters near both ends of the oskar mRNA 3′ UTR. Here we show that some BREs are bifunctional: both clusters of BREs contribute to translational repression, and the 3′ cluster has an additional role in release from BRE-dependent repression. Remarkably, both BRE functions can be provided in trans by an oskar mRNA with wild-type BREs that is itself unable to encode Oskar protein. Regulation in trans is likely enabled by assembly of oskar transcripts in cytoplasmic RNPs. Concentration of transcripts in such RNPs is common, and trans regulation of mRNAs may therefore be widespread." @default.
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• W2091215457 date "2010-03-01" @default.
• W2091215457 modified "2023-10-17" @default.
• W2091215457 title "BREs Mediate Both Repression and Activation of oskar mRNA Translation and Act In trans" @default.
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• W2091215457 doi "https://doi.org/10.1016/j.devcel.2009.12.021" @default.
• W2091215457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2841435" @default.
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