Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091216123> ?p ?o ?g. }
- W2091216123 endingPage "E833" @default.
- W2091216123 startingPage "E828" @default.
- W2091216123 abstract "Nutrients that induce biphasic insulin release, such as glucose and leucine, provide acetyl-CoA and anaplerotic input in the β-cell. The first phase of release requires increased ATP production leading to increased intracellular Ca 2+ concentration ([Ca 2+ ] i ). The second phase requires increased [Ca 2+ ] i and anaplerosis. There is strong evidence to indicate that the second phase is due to augmentation of Ca 2+ -stimulated release via the K ATP channel-independent pathway. To test whether the phenomenon of time-dependent potentiation (TDP) has similar properties to the ATP-sensitive K + channel-independent pathway, we monitored the ability of different agents that provide acetyl-CoA and anaplerotic input or both of these inputs to induce TDP. The results show that anaplerotic input is sufficient to induce TDP. Interestingly, among the agents tested, the nonsecretagogue glutamine, the nonhydrolyzable analog of leucine aminobicyclo[2.2.1]heptane-2-carboxylic acid, and succinic acid methyl ester all induced TDP, and all significantly increased α-ketoglutarate levels in the islets. In conclusion, anaplerosis that enhances the supply and utilization of α-ketoglutarate in the tricarboxylic acid cycle appears to play an essential role in the generation of TDP." @default.
- W2091216123 created "2016-06-24" @default.
- W2091216123 creator A5006957202 @default.
- W2091216123 creator A5022712558 @default.
- W2091216123 creator A5034453539 @default.
- W2091216123 creator A5079710351 @default.
- W2091216123 creator A5085352334 @default.
- W2091216123 date "2004-11-01" @default.
- W2091216123 modified "2023-09-25" @default.
- W2091216123 title "Anaplerotic input is sufficient to induce time-dependent potentiation of insulin release in rat pancreatic islets" @default.
- W2091216123 cites W1499384204 @default.
- W2091216123 cites W1510217511 @default.
- W2091216123 cites W1546970082 @default.
- W2091216123 cites W1572077460 @default.
- W2091216123 cites W1580746914 @default.
- W2091216123 cites W1585816034 @default.
- W2091216123 cites W159696395 @default.
- W2091216123 cites W1834004242 @default.
- W2091216123 cites W1918502072 @default.
- W2091216123 cites W1966852147 @default.
- W2091216123 cites W1970958676 @default.
- W2091216123 cites W1972899406 @default.
- W2091216123 cites W1975902039 @default.
- W2091216123 cites W1980164069 @default.
- W2091216123 cites W1987787422 @default.
- W2091216123 cites W1989911135 @default.
- W2091216123 cites W1990024356 @default.
- W2091216123 cites W1999655968 @default.
- W2091216123 cites W2006530891 @default.
- W2091216123 cites W2013556712 @default.
- W2091216123 cites W2017272722 @default.
- W2091216123 cites W2017966908 @default.
- W2091216123 cites W2018659646 @default.
- W2091216123 cites W2020057144 @default.
- W2091216123 cites W2022185109 @default.
- W2091216123 cites W2023110509 @default.
- W2091216123 cites W2025004003 @default.
- W2091216123 cites W2041154114 @default.
- W2091216123 cites W2042606425 @default.
- W2091216123 cites W2050656247 @default.
- W2091216123 cites W2052920139 @default.
- W2091216123 cites W2058243996 @default.
- W2091216123 cites W2059628066 @default.
- W2091216123 cites W2068803404 @default.
- W2091216123 cites W2070652664 @default.
- W2091216123 cites W2075380931 @default.
- W2091216123 cites W2078312203 @default.
- W2091216123 cites W2079565796 @default.
- W2091216123 cites W2094571862 @default.
- W2091216123 cites W2099620504 @default.
- W2091216123 cites W2120711739 @default.
- W2091216123 cites W2123308029 @default.
- W2091216123 cites W2135154530 @default.
- W2091216123 cites W2153347819 @default.
- W2091216123 cites W2156613146 @default.
- W2091216123 cites W2157865424 @default.
- W2091216123 cites W2159222406 @default.
- W2091216123 cites W2164128040 @default.
- W2091216123 cites W2174914196 @default.
- W2091216123 cites W2233127634 @default.
- W2091216123 cites W2412120034 @default.
- W2091216123 cites W2414940966 @default.
- W2091216123 cites W2416475871 @default.
- W2091216123 cites W2471353690 @default.
- W2091216123 cites W4244503335 @default.
- W2091216123 cites W4245584534 @default.
- W2091216123 doi "https://doi.org/10.1152/ajpendo.00381.2003" @default.
- W2091216123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15475511" @default.
- W2091216123 hasPublicationYear "2004" @default.
- W2091216123 type Work @default.
- W2091216123 sameAs 2091216123 @default.
- W2091216123 citedByCount "11" @default.
- W2091216123 countsByYear W20912161232012 @default.
- W2091216123 countsByYear W20912161232013 @default.
- W2091216123 countsByYear W20912161232014 @default.
- W2091216123 crossrefType "journal-article" @default.
- W2091216123 hasAuthorship W2091216123A5006957202 @default.
- W2091216123 hasAuthorship W2091216123A5022712558 @default.
- W2091216123 hasAuthorship W2091216123A5034453539 @default.
- W2091216123 hasAuthorship W2091216123A5079710351 @default.
- W2091216123 hasAuthorship W2091216123A5085352334 @default.
- W2091216123 hasConcept C134018914 @default.
- W2091216123 hasConcept C165135838 @default.
- W2091216123 hasConcept C185592680 @default.
- W2091216123 hasConcept C2776580952 @default.
- W2091216123 hasConcept C2779306644 @default.
- W2091216123 hasConcept C2779349466 @default.
- W2091216123 hasConcept C515207424 @default.
- W2091216123 hasConcept C55493867 @default.
- W2091216123 hasConcept C62231903 @default.
- W2091216123 hasConcept C79879829 @default.
- W2091216123 hasConcept C86803240 @default.
- W2091216123 hasConcept C95444343 @default.
- W2091216123 hasConceptScore W2091216123C134018914 @default.
- W2091216123 hasConceptScore W2091216123C165135838 @default.
- W2091216123 hasConceptScore W2091216123C185592680 @default.
- W2091216123 hasConceptScore W2091216123C2776580952 @default.
- W2091216123 hasConceptScore W2091216123C2779306644 @default.