FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091216659> ?p ?o ?g. }

• W2091216659 endingPage "3903" @default.
• W2091216659 startingPage "3890" @default.
• W2091216659 abstract "Interleukin-6 (IL-6) is a proinflammatory cytokine that plays multiple roles in the central nervous system during infections and injuries. Although this molecule is capable of stimulating the release of ACTH and glucocorticoids, it has been demonstrated that a single injection of IL-6 fails to activate the paraventricular nucleus (PVN) neurons that control the hypothalamic-pituitary-adrenal axis. The observation that IL-6 receptor (IL-6R) is up-regulated in the brain during endotoxemia led us to hypothesize that prior induction of IL-6R synthesis could amplify the effect of circulating IL-6 on the neuroendocrine response. Rats received a first iv injection of either bacterial lipopolysaccharide (LPS; 5 μg) or vehicle solution. After a 6-h waiting period, they received a second iv injection of either recombinant rat IL-6 or vehicle solution and were killed 1 h thereafter. Using in situ hybridization, we observed that IL-6R was barely expressed in the PVN under basal conditions, but was rapidly produced in response to LPS. IL-6 itself was also able to induce the synthesis of its own receptor along cerebral blood vessels, and this effect extended to several parenchymal structures, including the PVN, when the cytokine was administrated after LPS. In agreement with our hypothesis, we found that IL-6 injected in LPS-pretreated rats stimulated PVN neurons, as revealed by the expression of CRF primary transcript and c-fos messenger RNA, an immediate early gene used as a marker of cellular activation. A significant increase in plasma corticosterone levels was also found in animals that received iv IL-6 injection after being pretreated 6 h before with the very low dose of LPS. The fact that IL-6 alone or injected after LPS treatment was unable to induce cyclooxygenase-2 synthesis is an argument in favor of a PG-independent mechanism. The relative contribution of IL-6 in stimulating CRF expression in the PVN and neural activity throughout the brain during endotoxemia was also investigated in IL-6-deficient mice after an ip injection of LPS. The endotoxin induced similar c-fos and CRF expression patterns in knockout and wild-type mice, but the expression levels were generally higher and/or lasted longer in wild-type animals. Taken together, physiological changes that may include the induction of IL-6R synthesis seem to be necessary for IL-6 to activate PVN neurons. Moreover, although IL-6 does not appear essential during the early phases of endotoxemia, this cytokine is required during the later phases to prolong the activation of neural cells throughout the brain and to maintain CRF expression in the PVN neurons that control the hypothalamic-pituitary-adrenal axis." @default.
• W2091216659 created "2016-06-24" @default.
• W2091216659 creator A5027140673 @default.
• W2091216659 creator A5033616546 @default.
• W2091216659 date "1999-09-01" @default.
• W2091216659 modified "2023-10-18" @default.
• W2091216659 title "Interleukin-6 Is a Needed Proinflammatory Cytokine in the Prolonged Neural Activity and Transcriptional Activation of Corticotropin-Releasing Factor during Endotoxemia1" @default.
• W2091216659 cites W1486822318 @default.
• W2091216659 cites W1586109329 @default.
• W2091216659 cites W1898252364 @default.
• W2091216659 cites W1948313709 @default.
• W2091216659 cites W1950728343 @default.
• W2091216659 cites W1966985410 @default.
• W2091216659 cites W1970514930 @default.
• W2091216659 cites W1971701882 @default.
• W2091216659 cites W1971747646 @default.
• W2091216659 cites W1974762130 @default.
• W2091216659 cites W1987150557 @default.
• W2091216659 cites W1991522670 @default.
• W2091216659 cites W1997596092 @default.
• W2091216659 cites W1998086688 @default.
• W2091216659 cites W2002283782 @default.
• W2091216659 cites W2007451263 @default.
• W2091216659 cites W2009837389 @default.
• W2091216659 cites W2013271691 @default.
• W2091216659 cites W2013524799 @default.
• W2091216659 cites W2018865313 @default.
• W2091216659 cites W2021418970 @default.
• W2091216659 cites W2023299675 @default.
• W2091216659 cites W2024248428 @default.
• W2091216659 cites W2027912654 @default.
• W2091216659 cites W2032113087 @default.
• W2091216659 cites W2036380865 @default.
• W2091216659 cites W2038163560 @default.
• W2091216659 cites W2038220228 @default.
• W2091216659 cites W2040594794 @default.
• W2091216659 cites W2053837165 @default.
• W2091216659 cites W2054979170 @default.
• W2091216659 cites W2056402891 @default.
• W2091216659 cites W2057018521 @default.
• W2091216659 cites W2057771447 @default.
• W2091216659 cites W2059066496 @default.
• W2091216659 cites W2061314718 @default.
• W2091216659 cites W2062102197 @default.
• W2091216659 cites W2063310609 @default.
• W2091216659 cites W2064231933 @default.
• W2091216659 cites W2066146595 @default.
• W2091216659 cites W2067761476 @default.
• W2091216659 cites W2080742766 @default.
• W2091216659 cites W2081476431 @default.
• W2091216659 cites W2081489881 @default.
• W2091216659 cites W2086654320 @default.
• W2091216659 cites W2091270313 @default.
• W2091216659 cites W2093844611 @default.
• W2091216659 cites W2099662728 @default.
• W2091216659 cites W2100436346 @default.
• W2091216659 cites W2108661128 @default.
• W2091216659 cites W2122175586 @default.
• W2091216659 cites W2126755143 @default.
• W2091216659 cites W2131220396 @default.
• W2091216659 cites W2135406130 @default.
• W2091216659 cites W2140213752 @default.
• W2091216659 cites W2147036191 @default.
• W2091216659 cites W2158406932 @default.
• W2091216659 cites W2167221318 @default.
• W2091216659 cites W4247615759 @default.
• W2091216659 doi "https://doi.org/10.1210/endo.140.9.6983" @default.
• W2091216659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10465257" @default.
• W2091216659 hasPublicationYear "1999" @default.
• W2091216659 type Work @default.
• W2091216659 sameAs 2091216659 @default.
• W2091216659 citedByCount "127" @default.
• W2091216659 countsByYear W20912166592012 @default.
• W2091216659 countsByYear W20912166592013 @default.
• W2091216659 countsByYear W20912166592014 @default.
• W2091216659 countsByYear W20912166592015 @default.
• W2091216659 countsByYear W20912166592016 @default.
• W2091216659 countsByYear W20912166592017 @default.
• W2091216659 countsByYear W20912166592018 @default.
• W2091216659 countsByYear W20912166592019 @default.
• W2091216659 countsByYear W20912166592020 @default.
• W2091216659 countsByYear W20912166592021 @default.
• W2091216659 countsByYear W20912166592022 @default.
• W2091216659 crossrefType "journal-article" @default.
• W2091216659 hasAuthorship W2091216659A5027140673 @default.
• W2091216659 hasAuthorship W2091216659A5033616546 @default.
• W2091216659 hasBestOaLocation W20912166591 @default.
• W2091216659 hasConcept C104317684 @default.
• W2091216659 hasConcept C105580179 @default.
• W2091216659 hasConcept C126322002 @default.
• W2091216659 hasConcept C134018914 @default.
• W2091216659 hasConcept C164027704 @default.
• W2091216659 hasConcept C170493617 @default.
• W2091216659 hasConcept C185592680 @default.
• W2091216659 hasConcept C2776914184 @default.
• W2091216659 hasConcept C2777003273 @default.
• W2091216659 hasConcept C2778024521 @default.
• W2091216659 hasConcept C2778690821 @default.

• next