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- W2091219292 abstract "We demonstrate that the digestion of template DNAs with restriction endonucleases prior to Alu polymerase chain reaction (restricted Alu-PCR) reduces the complexity of the Alu-primed amplification patterns of human DNA in somatic cell hybrids and allows a direct informative comparison of these patterns. A comparison of restricted Alu-PCR patterns of a monochromosomal hybrid retaining a human chromosome 17 (MH22-6) and a hybrid retaining a human chromosome 17 deleted for band p11.2 (DH110-D1) revealed four Alu-PCR products that were present in the former but absent in the latter hybrid. Hybridization of these fragments to the total Alu-PCR amplification products of the two hybrids confirmed their absence in DH110-D1 amplification products. Hybridization to a panel of somatic cell hybrids indicated that two of these fragments were deleted in the hybrid DH110-D1 and mapped to 17p11.2, as expected. However, two additional fragments were not deleted in the hybrid DH110-D1 and mapped to other regions of chromosome 17. An insertion-deletion polymorphism was associated with one of the latter fragments, which may be the mechanism for the lack of its amplification in the hybrid DH110-D1. Restricted Alu-PCR should enhance the applications of Alu-PCR and provides a new method for the identification of chromosome-specific polymorphic markers." @default.
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- W2091219292 date "1991-01-01" @default.
- W2091219292 modified "2023-09-25" @default.
- W2091219292 title "Isolation of region-specific and polymorphic markers from chromosome 17 by restricted Alu polymerase chain reaction" @default.
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- W2091219292 doi "https://doi.org/10.1016/0888-7543(91)90217-3" @default.
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