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• W2091220511 abstract "OBJECTIVES: To study the effect of pioglitazone (PIO) on plasma resistin concentration, endogenous glucose production (EGP), and hepatic fat content (HFC) in patients with type II diabetes (T2DM). SUBJECTS: A total of 13 T2DM patients (age=51±2 y, BMI=29.7±1.1 kg/m2, HbA1c=8.0±0.5%). METHODS: HFC (magnetic resonance spectroscopy) and basal plasma resistin concentration were quantitated before and after PIO treatment (45 mg/day) for 16 weeks. Subjects received a 3 h euglycemic insulin (100 mU/m2/min) clamp with 3-[3H] glucose to determine rates of EGP and tissue glucose disappearance (Rd) before and after PIO. RESULTS: PIO reduced fasting plasma glucose (10.3±0.7 to 7.6±0.6 mmol/l, P<0.001) and HbA1c (8.0±0.4 to 6.8±0.3%, P<0.001) despite increased body weight (83.2±3.4 to 86.3±3.4 kg, P<0.001). PIO improved Rd (4.9±0.4 to 6.6±0.5 mg/kg/min, P<0.005) and reduced EGP (0.22±0.04 to 0.06±0.02 mg/kg/min, P<0.01) during the insulin clamp. Following PIO, HFC decreased from 21.1±3.5 to 11.2±2.1% (P<0.005), and plasma resistin decreased from 5.3±0.6 to 3.5±0.3 ng/ml (P<0.01). Plasma resistin concentration correlated positively with HFC before (r=0.58, P<0.05) and after (r=0.55, P<0.05) PIO treatment. Taken collectively, plasma resistin concentration, before and after PIO treatment, correlated positively with hepatic fat content (r=0.66, P<0.001) and EGP during the insulin clamp (r=0.41, P<0.05). However, the plasma resistin concentration did not correlate with whole body glucose disposal (Rd) during the insulin clamp either before (r=−0.18, P=NS) or after (r=−0.13, P=NS) PIO treatment. CONCLUSIONS: PIO treatment in T2DM causes a significant decrease in plasma resistin concentration. The decrease in plasma resistin is positively correlated with the decrease in hepatic fat content and improvement in hepatic insulin sensitivity." @default.
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• W2091220511 date "2004-03-16" @default.
• W2091220511 modified "2023-10-12" @default.
• W2091220511 title "Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients" @default.
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• W2091220511 doi "https://doi.org/10.1038/sj.ijo.0802625" @default.
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