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- W2091222739 abstract "The resistance of cancer cells to chemotherapeutic drugs represents a major problem in cancer treatment. Despite all efforts, mechanisms of resistance have not yet been elucidated. To reveal proteins that could be involved in resistance to taxanes, we compared protein expression in whole cell lysates of SK-BR-3 breast cancer cells sensitive to paclitaxel and in lysates of the same line with acquired resistance to paclitaxel. The resistant SK-BR-3 cell line was established in our lab. Protein separation was achieved using high-resolution 2D-electrophoresis, computer analysis and mass spectro-metry. With these techniques we identified four proteins with different expression in resistant SK-BR-3 cells, i.e., serpin B3, serpin B4, heat shock protein 27 (all three upregulated) and cytokeratin 18 (downregulated). Observed changes were confirmed using western blot analysis. This study suggests new directions worthy of further study in the effort to reveal the mechanism of resistance to paclitaxel in breast cancer cells." @default.
- W2091222739 created "2016-06-24" @default.
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- W2091222739 date "2014-06-03" @default.
- W2091222739 modified "2023-10-02" @default.
- W2091222739 title "Differentially expressed proteins in human breast cancer cells sensitive and resistant to paclitaxel" @default.
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- W2091222739 doi "https://doi.org/10.3892/ijo.2014.2484" @default.
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