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- W2091222869 abstract "Previous studies have reported cross-reactivity between latex and grass allergens. Inhibition studies have indicated cross-reactivity of IgE with latex and grass pollen proteins. A panel consisting of a few recombinant allergens, namely rPhI p 1, rPhl p 2, rPhl p 5 and profilin, was sufficient to diagnose grass pollen allergy in patients allergic to grass pollen. Serum samples from 528 consecutive outpatients with IgE antibodies towards at least one allergen (IgE level > 0.35 kAU/L) were selected for this retrospective study. Total and specific serum IgE to rPhl p 1, rPhl p 2, rPhl p 5, rBet v 1, rBet v 2, latex, birch, hazel, mugwort, wall pellitory, Dermatophagoides pteronissinus, Alternaria tenuis, cat and apple were measured by the immunoenzymatic capsulated hydrophilic carrier polymer (CAP) FEIA system (Pharmacia & Upjohn). Of 123 polysensitized patients with antilatex Ig1E, 12 (9.76%) had symptoms after latex exposure. Ten of 12 subjects monosensitized to latex had symptoms after latex exposure. Symptomatic patients had higher IgE levels to latex than symptomless patients (P = 0.046). A higher prevalence of antilatex IgE was seen in sera containing specific IgE to rPhl p 1, rPhl p 5 and rBet v 2. A good correlation (Spearman's r = 0.52; P = 0.001) between high levels of antilatex IgE and total serum IgE was found. The findings of the present study may support the concept that a high proportion of sera containing IgE to rBet v 2, rPhl p 1 and rPhl p 5 simultaneously contain antilatex IgE. Therefore, patients with specific IgE to these recombinant allergens with no history of current latex exposure may need additional evaluation." @default.
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- W2091222869 date "2001-01-01" @default.
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- W2091222869 title "Prevalence of IgE antibodies to an extract from rubber tree (Hevea brasiliensis) latex and recombinant pollen allergens (Phl P 1, Phl P 2, Phl P 5, Bet v 1 and Bet v 2) in the sera of Italian atopic patients" @default.
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- W2091222869 doi "https://doi.org/10.1046/j.1440-1592.2001.00221.x" @default.
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