Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091223189> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2091223189 endingPage "48" @default.
- W2091223189 startingPage "43" @default.
- W2091223189 abstract "Cultured mouse blastocysts were treated with 5-bromodeoxyuridine (BUdR) for 24-h periods at various stages to determine the effect on development of the inner cell mass (ICM). ICM development was most sensitive to BUdR (10-7–10-6 M) when embryos were treated at the late blastocyst stage, and the sensitivity decreased at each consecutive stage. The decrease in ICM sensitivity corresponded with the time of morphological differentiation into endoderm and ectoderm. At low concentrations (10-8–10-7 M), BUdR also frequently caused abnormal differentiation of ICMs, which appeared flat and had small ectodermal cores. Light microscopic examination of thick sections revealed that ectoderm cells of abnormal embryos contained numerous vacuoles, which were absent from control embryos. Endoderm cells of these embryos had fewer microvilli than control embryos and lacked apical vacuoles. Autoradiography showed that the amount of 3H-BUdR incorporated into the DNA decreased as embryos developed, and this decrease almost completely accounted for the decrease in the BUdR effect. We conclude that BUdR treatment of mouse embryos impairs gene expression necessary for endoderm and ectoderm differentiation and that the critical period for this effect includes, but may not be limited to, the late blastocyst and attachment stages." @default.
- W2091223189 created "2016-06-24" @default.
- W2091223189 creator A5021147008 @default.
- W2091223189 creator A5043069275 @default.
- W2091223189 date "1977-10-01" @default.
- W2091223189 modified "2023-10-17" @default.
- W2091223189 title "Interference with in vitro Development of Mouse Inner Cell Mass by 24-h Treatment with 5-bromodeoxyuridine" @default.
- W2091223189 cites W1586947583 @default.
- W2091223189 cites W1864542222 @default.
- W2091223189 cites W1875056245 @default.
- W2091223189 cites W1980183446 @default.
- W2091223189 cites W1983200031 @default.
- W2091223189 cites W1987209593 @default.
- W2091223189 cites W2000987057 @default.
- W2091223189 cites W2002547458 @default.
- W2091223189 cites W2009386982 @default.
- W2091223189 cites W2022430120 @default.
- W2091223189 cites W2025126023 @default.
- W2091223189 cites W2037054237 @default.
- W2091223189 cites W2042639792 @default.
- W2091223189 cites W2048722178 @default.
- W2091223189 cites W2052831612 @default.
- W2091223189 cites W2054040870 @default.
- W2091223189 cites W2074758544 @default.
- W2091223189 cites W2077627621 @default.
- W2091223189 cites W2085437047 @default.
- W2091223189 cites W2107120576 @default.
- W2091223189 cites W2143156206 @default.
- W2091223189 cites W2284098868 @default.
- W2091223189 cites W2329528674 @default.
- W2091223189 cites W2333144105 @default.
- W2091223189 doi "https://doi.org/10.1111/j.1432-0436.1977.tb01517.x" @default.
- W2091223189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/590662" @default.
- W2091223189 hasPublicationYear "1977" @default.
- W2091223189 type Work @default.
- W2091223189 sameAs 2091223189 @default.
- W2091223189 citedByCount "9" @default.
- W2091223189 countsByYear W20912231892018 @default.
- W2091223189 crossrefType "journal-article" @default.
- W2091223189 hasAuthorship W2091223189A5021147008 @default.
- W2091223189 hasAuthorship W2091223189A5043069275 @default.
- W2091223189 hasConcept C104317684 @default.
- W2091223189 hasConcept C148738053 @default.
- W2091223189 hasConcept C153911025 @default.
- W2091223189 hasConcept C159399396 @default.
- W2091223189 hasConcept C16685009 @default.
- W2091223189 hasConcept C196843134 @default.
- W2091223189 hasConcept C2777164004 @default.
- W2091223189 hasConcept C2778177303 @default.
- W2091223189 hasConcept C2778260397 @default.
- W2091223189 hasConcept C2779329299 @default.
- W2091223189 hasConcept C54355233 @default.
- W2091223189 hasConcept C62112901 @default.
- W2091223189 hasConcept C71924100 @default.
- W2091223189 hasConcept C86803240 @default.
- W2091223189 hasConcept C87073359 @default.
- W2091223189 hasConcept C95444343 @default.
- W2091223189 hasConceptScore W2091223189C104317684 @default.
- W2091223189 hasConceptScore W2091223189C148738053 @default.
- W2091223189 hasConceptScore W2091223189C153911025 @default.
- W2091223189 hasConceptScore W2091223189C159399396 @default.
- W2091223189 hasConceptScore W2091223189C16685009 @default.
- W2091223189 hasConceptScore W2091223189C196843134 @default.
- W2091223189 hasConceptScore W2091223189C2777164004 @default.
- W2091223189 hasConceptScore W2091223189C2778177303 @default.
- W2091223189 hasConceptScore W2091223189C2778260397 @default.
- W2091223189 hasConceptScore W2091223189C2779329299 @default.
- W2091223189 hasConceptScore W2091223189C54355233 @default.
- W2091223189 hasConceptScore W2091223189C62112901 @default.
- W2091223189 hasConceptScore W2091223189C71924100 @default.
- W2091223189 hasConceptScore W2091223189C86803240 @default.
- W2091223189 hasConceptScore W2091223189C87073359 @default.
- W2091223189 hasConceptScore W2091223189C95444343 @default.
- W2091223189 hasIssue "1-3" @default.
- W2091223189 hasLocation W20912231891 @default.
- W2091223189 hasLocation W20912231892 @default.
- W2091223189 hasOpenAccess W2091223189 @default.
- W2091223189 hasPrimaryLocation W20912231891 @default.
- W2091223189 hasRelatedWork W1773860140 @default.
- W2091223189 hasRelatedWork W1989536943 @default.
- W2091223189 hasRelatedWork W2003026164 @default.
- W2091223189 hasRelatedWork W2074103120 @default.
- W2091223189 hasRelatedWork W2091223189 @default.
- W2091223189 hasRelatedWork W2097300309 @default.
- W2091223189 hasRelatedWork W2123965772 @default.
- W2091223189 hasRelatedWork W2373479018 @default.
- W2091223189 hasRelatedWork W2419358061 @default.
- W2091223189 hasRelatedWork W4309154520 @default.
- W2091223189 hasVolume "9" @default.
- W2091223189 isParatext "false" @default.
- W2091223189 isRetracted "false" @default.
- W2091223189 magId "2091223189" @default.
- W2091223189 workType "article" @default.