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- W2091223566 abstract "Glucocorticoids (GCs) have impressive anti-inflammatory and immunosuppressive effects and show a diversity of actions across a variety of cell phenotypes. Implicit in efforts to optimize GCs as anti-inflammatory agents for any or all indications is the notion that the relevant mechanism(s) of action of GCs are fully elucidated. However, recent advances in understanding GC signalling mechanisms have revealed remarkable complexity and contextual dependence, calling into question whether the mechanisms of action are sufficiently well-described to embark on optimization. In the current review, we address evidence for differences in the mechanism of action in different cell types and contexts, and discuss contrasts in mechanisms of glucocorticoid insensitivity, with a focus on asthma and Chronic Obstructive Pulmonary Disease (COPD). Given this complexity, we consider the potential breadth of impact and selectivity of strategies directed to reversing the glucocorticoid insensitivity." @default.
- W2091223566 created "2016-06-24" @default.
- W2091223566 creator A5010376459 @default.
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- W2091223566 creator A5056305060 @default.
- W2091223566 creator A5084034730 @default.
- W2091223566 creator A5085630051 @default.
- W2091223566 date "2015-06-01" @default.
- W2091223566 modified "2023-10-12" @default.
- W2091223566 title "Heterogeneity in mechanisms influencing glucocorticoid sensitivity: The need for a systems biology approach to treatment of glucocorticoid-resistant inflammation" @default.
- W2091223566 cites W1495367679 @default.
- W2091223566 cites W1495764983 @default.
- W2091223566 cites W1517747325 @default.
- W2091223566 cites W1531159055 @default.
- W2091223566 cites W1534228852 @default.
- W2091223566 cites W1565248052 @default.
- W2091223566 cites W1582154931 @default.
- W2091223566 cites W1586640515 @default.
- W2091223566 cites W1591311222 @default.
- W2091223566 cites W1628031477 @default.
- W2091223566 cites W1684018548 @default.
- W2091223566 cites W1689343528 @default.
- W2091223566 cites W1730050290 @default.
- W2091223566 cites W1825815388 @default.
- W2091223566 cites W1857877161 @default.
- W2091223566 cites W1899889608 @default.
- W2091223566 cites W1935322656 @default.
- W2091223566 cites W1942562504 @default.
- W2091223566 cites W1945512486 @default.
- W2091223566 cites W1958721249 @default.
- W2091223566 cites W1963612767 @default.
- W2091223566 cites W1964635429 @default.
- W2091223566 cites W1966814333 @default.
- W2091223566 cites W1967795360 @default.
- W2091223566 cites W1968345969 @default.
- W2091223566 cites W1968671826 @default.
- W2091223566 cites W1972437652 @default.
- W2091223566 cites W1973659368 @default.
- W2091223566 cites W1977380429 @default.
- W2091223566 cites W1980105210 @default.
- W2091223566 cites W1980675454 @default.
- W2091223566 cites W1981233259 @default.
- W2091223566 cites W1981384391 @default.
- W2091223566 cites W1981399070 @default.
- W2091223566 cites W1981555245 @default.
- W2091223566 cites W1982152078 @default.
- W2091223566 cites W1984592139 @default.
- W2091223566 cites W1989701451 @default.
- W2091223566 cites W1991607289 @default.
- W2091223566 cites W1992339013 @default.
- W2091223566 cites W1992978140 @default.
- W2091223566 cites W1993535064 @default.
- W2091223566 cites W1994562226 @default.
- W2091223566 cites W1994871447 @default.
- W2091223566 cites W1995139242 @default.
- W2091223566 cites W1995902693 @default.
- W2091223566 cites W1997510672 @default.
- W2091223566 cites W1998269768 @default.
- W2091223566 cites W2000167866 @default.
- W2091223566 cites W2002245140 @default.
- W2091223566 cites W2003189930 @default.
- W2091223566 cites W2003274919 @default.
- W2091223566 cites W2003337073 @default.
- W2091223566 cites W2003945422 @default.
- W2091223566 cites W2004396927 @default.
- W2091223566 cites W2004415436 @default.
- W2091223566 cites W2005126850 @default.
- W2091223566 cites W2005473631 @default.
- W2091223566 cites W2006048948 @default.
- W2091223566 cites W2006599479 @default.
- W2091223566 cites W2008654807 @default.
- W2091223566 cites W2008781112 @default.
- W2091223566 cites W2009638401 @default.
- W2091223566 cites W2010984276 @default.
- W2091223566 cites W2012757036 @default.
- W2091223566 cites W2013105339 @default.
- W2091223566 cites W2013362232 @default.
- W2091223566 cites W2013407710 @default.
- W2091223566 cites W2013980575 @default.
- W2091223566 cites W2015887691 @default.
- W2091223566 cites W2016481275 @default.
- W2091223566 cites W2017783654 @default.
- W2091223566 cites W2017916832 @default.
- W2091223566 cites W2018809578 @default.
- W2091223566 cites W2021132146 @default.
- W2091223566 cites W2024259316 @default.
- W2091223566 cites W2024625607 @default.
- W2091223566 cites W2027749435 @default.
- W2091223566 cites W2030097812 @default.
- W2091223566 cites W2032735800 @default.
- W2091223566 cites W2033712059 @default.
- W2091223566 cites W2034011097 @default.
- W2091223566 cites W2035254675 @default.
- W2091223566 cites W2035276487 @default.
- W2091223566 cites W2038626605 @default.
- W2091223566 cites W2040291484 @default.
- W2091223566 cites W2040362986 @default.
- W2091223566 cites W2041056515 @default.