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- W2091224619 abstract "Interleukin 6 (IL-6) is one of the potent autocrine growth factors for mesangial cells. We investigated the signal transduction mechanism of IL-6 in cultured rat mesangial cells. IL-6 induced a transient increase of inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) followed by a transient and sustained increase of intracellular calcium concentration, suggesting that IL-6 stimulates phosphoinositide turnover. IL-6 also stimulated prostaglandin E2 (PGE2) production. The IL-6-concentration dependency in PGE2 production was similar to that in Ins 1,4,5-P3 production. We concluded that the action of IL-6 on mesangial cells is exerted at least partially through the enhancement of phosphoinositide turnover and PGE2 production." @default.
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- W2091224619 date "1991-07-01" @default.
- W2091224619 modified "2023-10-06" @default.
- W2091224619 title "Signal transduction mechanism of interleukin 6 in cultured rat mesangial cells" @default.
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- W2091224619 doi "https://doi.org/10.1016/0014-5793(91)80813-i" @default.
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