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• W2091224718 endingPage "391" @default.
• W2091224718 startingPage "379" @default.
• W2091224718 abstract "The satratoxins and other macrocyclic trichothecene mycotoxins are produced by Stachybotrys, a mold that is often found in water-damaged dwellings and office buildings. To test the potential immunomodulatory effects of these mycotoxins, RAW 264.7 murine macrophage cells were treated with various concentrations of satratoxin G (SG), isosatratoxin F (iSF), satratoxin H (SH), roridin A (RA), and verrucarin A (VA) for 48 h in the presence or absence of suboptimal concentra-tion of lipopolysaccharide (LPS, 50 ng/ml), and tumor necrosis factor-alpha (TNF-alpha ) and interleukin-6 (IL-6) production were assayed by enzyme-linked immunosorbent assay (ELISA). In LPS-stimulated cultures, TNF-alpha supernatant concentrations were significantly increased in the presence of 2.5, 2.5, and 1 ng/ml of SG, SH, and RA, respectively, whereas IL-6 concentrations were not affected by the same concentrations these macrocyclic trichothecenes. When cells that were treated with LPS and SG (2.5 ng/ml) were evaluated by real-time polymerase chain reaction (PCR),TNF-alpha mRNA was found to increase at 24, 36, and 48 h compared to control cells. At higher concentrations, cytokine production and cell viability were markedly impaired in LPS-stimulated cells. Without LPS stimulation, neither TNF-alpha, nor IL-6 was induced. These results indicate that low concentrations of macrocyclic trichothecenes superinduce expression of TNF-alpha, whereas higher concentrations of these toxins are cytotoxic and concurrently reduce cytokine production. The capacity of satratoxins and other macrocyclic trichothecenes to alter cytokine production may play an etiologic role in outbreaks of Stachybotrys-associated human illnesses." @default.
• W2091224718 created "2016-06-24" @default.
• W2091224718 creator A5012133684 @default.
• W2091224718 creator A5026204795 @default.
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• W2091224718 date "2003-01-01" @default.
• W2091224718 modified "2023-09-26" @default.
• W2091224718 title "Modulation of Lipopolysaccharide-Induced Proinflammatory Cytokine Production by Satratoxins and Other Macrocyclic Trichothecenes in the Murine Macrophage" @default.
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• W2091224718 doi "https://doi.org/10.1080/15287390306363" @default.
• W2091224718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12554543" @default.
• W2091224718 hasPublicationYear "2003" @default.
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