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- W2091227095 abstract "The nucleation field of calcium oxalate crystals (CaOx) was determined in urine at 37°C, in vitro, as a function of calcium [Ca] and oxalate [Ox] concentrations, and supersaturation β defined as a multiple of the thermodynamic solubility product of CaOx monohydrate. The diagram β = f[Ox] is clearly divided into two main fields by a curve above which CaOx crystals nucleate and grow. To each [Ox], corresponds therefore a minimal β below which nucleation does not occur. There is also a critical [Ox], about 0.16 mM, below which the nucleation of calcium oxalate crystals does not occur even at very large β values. We have next plotted, on the nucleation domain of CaOx defined in vitro, the individual calculated values of β and the measured [Ox] of 66 hypercalciuric stone formers. Fifty five percent of the patients were in the zone where nucleation has a high probability. After a calcium and oxalate restricted diet of respectively 400 mg/day and 40–70 mg/day, calciuria decreased while oxaluria and supersaturation either increased, decreased, or remained stable. Such variations allow to individualize patients with high or low lithogen risk." @default.
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- W2091227095 date "1988-03-01" @default.
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- W2091227095 title "In vitro and clinical study of oxalate influence on calcium oxalate crystal formation" @default.
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- W2091227095 doi "https://doi.org/10.1016/0022-0248(88)90097-8" @default.
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