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- W2091229213 abstract "Abstract The primary flow regulating mechanism in the gastric microcirculation of the rat was investigated using an in vivo microscopic technique. The effect of different vasoactive agents on the reactivity of submucosal and mucosal vessels to topically applied epinephrine was observed. Topically administered acetylcholine, histamine, serotonin, and compound 48 80 inhibited epinephrine induced vasoconstriction of small arterioles in the submucosa. Inhibition by compound 48 80 was associated with submucosal mast cell degranulation. Much larger doses of epinephrine (180 times that required for submucosal effects) applied to the mucosa resulted in slowing of flow and finally blanching but not constriction of mucosal vessels. The latter findings suggest that epinephrine diffused through the mucosa to constrict supplying arterioles in the submucosal plexus. Conclusions: (1) regulation of gastric mucosal blood flow is primarily via vasomotor effects on submucosal arterioles and not on mucosal microvessels; (2) no mucosal or submucosal arteriovenous anastomoses were seen; and (3) submucosal mast cells, through release of vasodilator amines, may modulate sympathetic vasoconstriction and thus may play a role in the local regulation of blood flow." @default.
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- W2091229213 date "1974-09-01" @default.
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- W2091229213 title "Vasoactive agents and the gastric microcirculation" @default.
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- W2091229213 doi "https://doi.org/10.1016/0026-2862(74)90086-7" @default.
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