Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091230907> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2091230907 endingPage "e95678" @default.
- W2091230907 startingPage "e95678" @default.
- W2091230907 abstract "The receptor for glycation end products (RAGE) has been previously implicated in shaping the adaptive immune response. RAGE is expressed in T cells after activation and constitutively in T cells from patients with diabetes. The effects of RAGE on adaptive immune responses are not clear: Previous reports show that RAGE blockade affects Th1 responses. To clarify the role of RAGE in adaptive immune responses and the mechanisms of its effects, we examined whether RAGE plays a role in T cell activation in a Th2 response involving ovalbumin (OVA)-induced asthma in mice. WT and RAGE deficient wild-type and OT-II mice, expressing a T cell receptor specific for OVA, were immunized intranasally with OVA. Lung cellular infiltration and T cell responses were analyzed by immunostaining, FACS, and multiplex bead analyses for cytokines. RAGE deficient mice showed reduced cellular infiltration in the bronchial alveolar lavage fluid and impaired T cell activation in the mediastinal lymph nodes when compared with WT mice. In addition, RAGE deficiency resulted in reduced OT-II T cell infiltration of the lung and impaired IFNγ and IL-5 production when compared with WT mice and reduced infiltration when transferred into WT hosts. When cultured under conditions favoring the differentiation of T cells subsets, RAGE deficient T cells showed reduced production of IFNγ but increased production of IL-17. Our data show a stimulatory role for RAGE in T activation in OVA-induced asthma. This role is largely mediated by the effects of RAGE on T cell proliferation and differentiation. These findings suggest that RAGE may play a regulatory role in T cell responses following immune activation." @default.
- W2091230907 created "2016-06-24" @default.
- W2091230907 creator A5013540321 @default.
- W2091230907 creator A5021474346 @default.
- W2091230907 creator A5022163031 @default.
- W2091230907 creator A5025956771 @default.
- W2091230907 creator A5051997889 @default.
- W2091230907 creator A5088476266 @default.
- W2091230907 date "2014-04-23" @default.
- W2091230907 modified "2023-10-03" @default.
- W2091230907 title "The Receptor for Advanced Glycation End Products (RAGE) Affects T Cell Differentiation in OVA Induced Asthma" @default.
- W2091230907 cites W1513611092 @default.
- W2091230907 cites W1825826250 @default.
- W2091230907 cites W1976552088 @default.
- W2091230907 cites W1981206112 @default.
- W2091230907 cites W2000281764 @default.
- W2091230907 cites W2015064865 @default.
- W2091230907 cites W2038534949 @default.
- W2091230907 cites W2054415919 @default.
- W2091230907 cites W2118046722 @default.
- W2091230907 cites W2130775443 @default.
- W2091230907 cites W2143239934 @default.
- W2091230907 cites W2150107415 @default.
- W2091230907 cites W2160960292 @default.
- W2091230907 cites W4243641777 @default.
- W2091230907 cites W4245060634 @default.
- W2091230907 doi "https://doi.org/10.1371/journal.pone.0095678" @default.
- W2091230907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3997417" @default.
- W2091230907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24759895" @default.
- W2091230907 hasPublicationYear "2014" @default.
- W2091230907 type Work @default.
- W2091230907 sameAs 2091230907 @default.
- W2091230907 citedByCount "39" @default.
- W2091230907 countsByYear W20912309072015 @default.
- W2091230907 countsByYear W20912309072016 @default.
- W2091230907 countsByYear W20912309072017 @default.
- W2091230907 countsByYear W20912309072018 @default.
- W2091230907 countsByYear W20912309072019 @default.
- W2091230907 countsByYear W20912309072020 @default.
- W2091230907 countsByYear W20912309072021 @default.
- W2091230907 countsByYear W20912309072022 @default.
- W2091230907 countsByYear W20912309072023 @default.
- W2091230907 crossrefType "journal-article" @default.
- W2091230907 hasAuthorship W2091230907A5013540321 @default.
- W2091230907 hasAuthorship W2091230907A5021474346 @default.
- W2091230907 hasAuthorship W2091230907A5022163031 @default.
- W2091230907 hasAuthorship W2091230907A5025956771 @default.
- W2091230907 hasAuthorship W2091230907A5051997889 @default.
- W2091230907 hasAuthorship W2091230907A5088476266 @default.
- W2091230907 hasBestOaLocation W20912309071 @default.
- W2091230907 hasConcept C126322002 @default.
- W2091230907 hasConcept C134018914 @default.
- W2091230907 hasConcept C169760540 @default.
- W2091230907 hasConcept C170493617 @default.
- W2091230907 hasConcept C185592680 @default.
- W2091230907 hasConcept C203014093 @default.
- W2091230907 hasConcept C2776090121 @default.
- W2091230907 hasConcept C2776946954 @default.
- W2091230907 hasConcept C2778857457 @default.
- W2091230907 hasConcept C71924100 @default.
- W2091230907 hasConcept C86803240 @default.
- W2091230907 hasConcept C8891405 @default.
- W2091230907 hasConceptScore W2091230907C126322002 @default.
- W2091230907 hasConceptScore W2091230907C134018914 @default.
- W2091230907 hasConceptScore W2091230907C169760540 @default.
- W2091230907 hasConceptScore W2091230907C170493617 @default.
- W2091230907 hasConceptScore W2091230907C185592680 @default.
- W2091230907 hasConceptScore W2091230907C203014093 @default.
- W2091230907 hasConceptScore W2091230907C2776090121 @default.
- W2091230907 hasConceptScore W2091230907C2776946954 @default.
- W2091230907 hasConceptScore W2091230907C2778857457 @default.
- W2091230907 hasConceptScore W2091230907C71924100 @default.
- W2091230907 hasConceptScore W2091230907C86803240 @default.
- W2091230907 hasConceptScore W2091230907C8891405 @default.
- W2091230907 hasIssue "4" @default.
- W2091230907 hasLocation W20912309071 @default.
- W2091230907 hasLocation W20912309072 @default.
- W2091230907 hasLocation W20912309073 @default.
- W2091230907 hasLocation W20912309074 @default.
- W2091230907 hasLocation W20912309075 @default.
- W2091230907 hasLocation W20912309076 @default.
- W2091230907 hasOpenAccess W2091230907 @default.
- W2091230907 hasPrimaryLocation W20912309071 @default.
- W2091230907 hasRelatedWork W1983325185 @default.
- W2091230907 hasRelatedWork W2038477076 @default.
- W2091230907 hasRelatedWork W2042573081 @default.
- W2091230907 hasRelatedWork W2062690124 @default.
- W2091230907 hasRelatedWork W2063619316 @default.
- W2091230907 hasRelatedWork W2162657772 @default.
- W2091230907 hasRelatedWork W2736540239 @default.
- W2091230907 hasRelatedWork W2741138112 @default.
- W2091230907 hasRelatedWork W2748952813 @default.
- W2091230907 hasRelatedWork W2764269354 @default.
- W2091230907 hasVolume "9" @default.
- W2091230907 isParatext "false" @default.
- W2091230907 isRetracted "false" @default.
- W2091230907 magId "2091230907" @default.
- W2091230907 workType "article" @default.