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• W2091233428 startingPage "1743" @default.
• W2091233428 abstract "Evidence suggests that depression is a risk factor for dementia; however, the relationship between the two conditions is not fully understood. A novel gene (TOMM40) has been consistently associated with Alzheimer's disease (AD), but has received no attention in depression. We conducted a three-level cross-sectional study to investigate the association of the TOMM40 rs2075650 SNP with depression. We recruited a community sample of 1220 participants (571 controls, 649 lifetime depression) to complete a psychiatric background questionnaire, the Brief Symptom Inventory, and Big Five Inventory at Level-1, 243 (102 controls, 97 remitted, 44 currently depressed) to complete a face-to-face clinical interview and neuropsychological testing at Level-2 and 58 (33 controls, 25 remitted) to complete an emotional face-processing task during fMRI at Level-3. Our results indicated that the TOMM40 rs2075650 G allele was a significant risk factor for lifetime depression (p = 0.00006) and, in depressed subjects, was a significant predictor of low extraversion (p = 0.009). Currently depressed risk allele carriers showed subtle executive dysfunction (p = 0.004) and decreased positive memory bias (p = 0.021) together with reduced activity in the posterior (p(FWE) = 0.045) and anterior (p(FWE) = 0.041) cingulate during sad face emotion processing. Our results suggest that TOMM40 rs2075650 may be a risk factor for the development of depression characterized by reduced extraversion, impaired executive function, and decreased positive emotional recall, and reduced top-down cortical control during sad emotion processing." @default.
• W2091233428 created "2016-06-24" @default.
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• W2091233428 date "2014-01-29" @default.
• W2091233428 modified "2023-10-16" @default.
• W2091233428 title "TOMM40 rs2075650 May Represent a New Candidate Gene for Vulnerability to Major Depressive Disorder" @default.
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• W2091233428 doi "https://doi.org/10.1038/npp.2014.22" @default.
• W2091233428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4023148" @default.
• W2091233428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24549102" @default.
• W2091233428 hasPublicationYear "2014" @default.
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