FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091233498> ?p ?o ?g. }

• W2091233498 abstract "Postmortem cerebellar and frontal cortical membrane homogenates from human alcoholics, control subjects without neurological or psychiatric illnesses, and rats that chronically drank alcohol were studied to determine the binding characteristics of an imidazobenzodiazepine, [3H]Ro 15-4513. This ligand binds to classical gamma-aminobutyric acidA (GABAA)/benzodiazepine receptors, as well as to a diazepam-insensitive site associated with the GABAA receptor complex in the cerebellar granule cell layer. There were no differences in the density of the binding sites between alcoholics and their controls, between alcohol-drinking AA rats that had a choice between 10% alcohol or water for about 10 weeks and their controls, or between Wistar rats that had been given 20% alcohol as their only fluid for 4 months and their controls, which were pair-fed isocalorically with sucrose. The affinity for the cerebellar binding of [3H]Ro 15-4513 was higher in the alcoholics than the controls. No differences were observed in the frontocortical binding. No affinity differences were observed in the rat models. There were no differences between the groups in the characteristics of [3H]Ro 15-4513 binding to human cerebellum in the presence of micromolar diazepam, thus revealing the diazepam-insensitive binding. When this component was subtracted from the total cerebellar binding, to reveal the diazepam sensitive binding, both the KD and Bmax were lower in the alcoholic than the control group. The binding of [3H]muscimol, a GABAA agonist, tended to be higher in the frontal cortices of alcoholics; a similar trend for greater effects was observed in the alcoholics for the GABA inhibition of [3H]Ro 15-4513 binding. These results suggest that no drastic changes occur through chronic alcohol abuse in the numbers of cerebellar and frontocortical benzodiazepine receptors in humans and rodent models; however, the data indicate that the alcoholics have either acquired or innate differences in classical benzodiazepine recognition sites of the cerebellum and in the coupling of these sites to GABAA sites in the frontal cortex, without any differences in cerebellar granule cell-specific diazepam-insensitive [3H]Ro 15-4513 binding sites." @default.
• W2091233498 created "2016-06-24" @default.
• W2091233498 creator A5014779572 @default.
• W2091233498 creator A5020523652 @default.
• W2091233498 creator A5049573329 @default.
• W2091233498 creator A5067508601 @default.
• W2091233498 creator A5073447113 @default.
• W2091233498 creator A5085521126 @default.
• W2091233498 date "1992-04-01" @default.
• W2091233498 modified "2023-09-26" @default.
• W2091233498 title "Cerebellar and frontal cortical benzodiazepine receptors in human alcoholics and chronically alcohol-drinking rats" @default.
• W2091233498 cites W159198934 @default.
• W2091233498 cites W1775749144 @default.
• W2091233498 cites W1972056987 @default.
• W2091233498 cites W1974908004 @default.
• W2091233498 cites W1983231582 @default.
• W2091233498 cites W1983967908 @default.
• W2091233498 cites W1984879608 @default.
• W2091233498 cites W1984895664 @default.
• W2091233498 cites W1987883434 @default.
• W2091233498 cites W1994831700 @default.
• W2091233498 cites W1999287710 @default.
• W2091233498 cites W2008646949 @default.
• W2091233498 cites W2008988654 @default.
• W2091233498 cites W2011058886 @default.
• W2091233498 cites W2014601859 @default.
• W2091233498 cites W2016606851 @default.
• W2091233498 cites W2017509694 @default.
• W2091233498 cites W2025810192 @default.
• W2091233498 cites W2028650350 @default.
• W2091233498 cites W2029227717 @default.
• W2091233498 cites W2040413542 @default.
• W2091233498 cites W2043813981 @default.
• W2091233498 cites W2050600804 @default.
• W2091233498 cites W2054272209 @default.
• W2091233498 cites W2056310348 @default.
• W2091233498 cites W2058714039 @default.
• W2091233498 cites W2059146457 @default.
• W2091233498 cites W2059864318 @default.
• W2091233498 cites W2060586131 @default.
• W2091233498 cites W2069996340 @default.
• W2091233498 cites W2072395864 @default.
• W2091233498 cites W2076501023 @default.
• W2091233498 cites W2092762285 @default.
• W2091233498 cites W2093117551 @default.
• W2091233498 cites W2093255668 @default.
• W2091233498 cites W2102131116 @default.
• W2091233498 cites W2128415935 @default.
• W2091233498 cites W2145845873 @default.
• W2091233498 cites W2148512456 @default.
• W2091233498 doi "https://doi.org/10.1016/0006-3223(92)90309-n" @default.
• W2091233498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1322720" @default.
• W2091233498 hasPublicationYear "1992" @default.
• W2091233498 type Work @default.
• W2091233498 sameAs 2091233498 @default.
• W2091233498 citedByCount "19" @default.
• W2091233498 countsByYear W20912334982012 @default.
• W2091233498 countsByYear W20912334982016 @default.
• W2091233498 countsByYear W20912334982021 @default.
• W2091233498 crossrefType "journal-article" @default.
• W2091233498 hasAuthorship W2091233498A5014779572 @default.
• W2091233498 hasAuthorship W2091233498A5020523652 @default.
• W2091233498 hasAuthorship W2091233498A5049573329 @default.
• W2091233498 hasAuthorship W2091233498A5067508601 @default.
• W2091233498 hasAuthorship W2091233498A5073447113 @default.
• W2091233498 hasAuthorship W2091233498A5085521126 @default.
• W2091233498 hasConcept C126322002 @default.
• W2091233498 hasConcept C134018914 @default.
• W2091233498 hasConcept C15744967 @default.
• W2091233498 hasConcept C168258287 @default.
• W2091233498 hasConcept C170493617 @default.
• W2091233498 hasConcept C185592680 @default.
• W2091233498 hasConcept C2776175493 @default.
• W2091233498 hasConcept C2778173252 @default.
• W2091233498 hasConcept C2778938600 @default.
• W2091233498 hasConcept C2779188335 @default.
• W2091233498 hasConcept C2779652256 @default.
• W2091233498 hasConcept C2781066024 @default.
• W2091233498 hasConcept C55493867 @default.
• W2091233498 hasConcept C71924100 @default.
• W2091233498 hasConcept C98274493 @default.
• W2091233498 hasConceptScore W2091233498C126322002 @default.
• W2091233498 hasConceptScore W2091233498C134018914 @default.
• W2091233498 hasConceptScore W2091233498C15744967 @default.
• W2091233498 hasConceptScore W2091233498C168258287 @default.
• W2091233498 hasConceptScore W2091233498C170493617 @default.
• W2091233498 hasConceptScore W2091233498C185592680 @default.
• W2091233498 hasConceptScore W2091233498C2776175493 @default.
• W2091233498 hasConceptScore W2091233498C2778173252 @default.
• W2091233498 hasConceptScore W2091233498C2778938600 @default.
• W2091233498 hasConceptScore W2091233498C2779188335 @default.
• W2091233498 hasConceptScore W2091233498C2779652256 @default.
• W2091233498 hasConceptScore W2091233498C2781066024 @default.
• W2091233498 hasConceptScore W2091233498C55493867 @default.
• W2091233498 hasConceptScore W2091233498C71924100 @default.
• W2091233498 hasConceptScore W2091233498C98274493 @default.
• W2091233498 hasLocation W20912334981 @default.
• W2091233498 hasLocation W20912334982 @default.
• W2091233498 hasOpenAccess W2091233498 @default.
• W2091233498 hasPrimaryLocation W20912334981 @default.

• next