Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091235730> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2091235730 endingPage "205" @default.
- W2091235730 startingPage "200" @default.
- W2091235730 abstract "The human μ‐opioid receptor and a mutant form, μS/T[i3+Cter]A, in which all Ser and Thr residues from the third cytoplasmic loop and C‐terminal domain were changed to Ala, were studied after expression in CHO‐K1 cells. Although the mutant receptors had similar affinities for agonists and EC 50 values for inhibition of adenylyl cyclase as compared to wild‐type receptors, the E max were almost 2‐fold decreased, suggesting a role of the mutated residues in G‐protein coupling. After chronic morphine or etorphine, the EC 50 values of the agonists were about 5‐fold increased at both receptors but the E max values were not altered; upon agonist withdrawal forskolin‐stimulated cAMP levels were increased to almost 200% of control levels. Sequestration and rapid down‐regulation of the μ‐opioid receptor were induced by DAGO and etorphine but not morphine. In contrast, the μS/T[i3+Cter]A receptor was not sequestered and was up‐regulated (150–380%) after treatment with agonists. The results indicate that the Ser and Thr residues in the third cytoplasmic loop and C‐terminus of the μ‐opioid receptor are not involved in the limited desensitization or in the adenylyl cyclase superactivation promoted by agonists but that their integrity and/or their phosphorylation is required in the intricate and coordinately regulated pathways involved in receptor signaling and trafficking." @default.
- W2091235730 created "2016-06-24" @default.
- W2091235730 creator A5009991476 @default.
- W2091235730 creator A5028105150 @default.
- W2091235730 creator A5029975428 @default.
- W2091235730 creator A5041670362 @default.
- W2091235730 creator A5050833243 @default.
- W2091235730 creator A5059143642 @default.
- W2091235730 date "1997-09-29" @default.
- W2091235730 modified "2023-10-14" @default.
- W2091235730 title "Agonist‐induced signaling and trafficking of the μ‐opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C‐terminal domain" @default.
- W2091235730 cites W1483189363 @default.
- W2091235730 cites W1536021967 @default.
- W2091235730 cites W1968107218 @default.
- W2091235730 cites W1970361438 @default.
- W2091235730 cites W2010227307 @default.
- W2091235730 cites W2016764094 @default.
- W2091235730 cites W2023078781 @default.
- W2091235730 cites W2032580095 @default.
- W2091235730 cites W2045960840 @default.
- W2091235730 cites W2078867772 @default.
- W2091235730 cites W2090845744 @default.
- W2091235730 cites W2095013577 @default.
- W2091235730 cites W2120701014 @default.
- W2091235730 cites W2127846911 @default.
- W2091235730 cites W2162170433 @default.
- W2091235730 cites W2163364932 @default.
- W2091235730 doi "https://doi.org/10.1016/s0014-5793(97)01124-1" @default.
- W2091235730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9350996" @default.
- W2091235730 hasPublicationYear "1997" @default.
- W2091235730 type Work @default.
- W2091235730 sameAs 2091235730 @default.
- W2091235730 citedByCount "50" @default.
- W2091235730 countsByYear W20912357302014 @default.
- W2091235730 crossrefType "journal-article" @default.
- W2091235730 hasAuthorship W2091235730A5009991476 @default.
- W2091235730 hasAuthorship W2091235730A5028105150 @default.
- W2091235730 hasAuthorship W2091235730A5029975428 @default.
- W2091235730 hasAuthorship W2091235730A5041670362 @default.
- W2091235730 hasAuthorship W2091235730A5050833243 @default.
- W2091235730 hasAuthorship W2091235730A5059143642 @default.
- W2091235730 hasBestOaLocation W20912357301 @default.
- W2091235730 hasConcept C115466790 @default.
- W2091235730 hasConcept C135285700 @default.
- W2091235730 hasConcept C14397066 @default.
- W2091235730 hasConcept C170493617 @default.
- W2091235730 hasConcept C185592680 @default.
- W2091235730 hasConcept C2778750930 @default.
- W2091235730 hasConcept C2778938600 @default.
- W2091235730 hasConcept C2779166228 @default.
- W2091235730 hasConcept C2779178603 @default.
- W2091235730 hasConcept C2779886867 @default.
- W2091235730 hasConcept C2781063702 @default.
- W2091235730 hasConcept C55493867 @default.
- W2091235730 hasConcept C75184817 @default.
- W2091235730 hasConcept C86803240 @default.
- W2091235730 hasConcept C95444343 @default.
- W2091235730 hasConceptScore W2091235730C115466790 @default.
- W2091235730 hasConceptScore W2091235730C135285700 @default.
- W2091235730 hasConceptScore W2091235730C14397066 @default.
- W2091235730 hasConceptScore W2091235730C170493617 @default.
- W2091235730 hasConceptScore W2091235730C185592680 @default.
- W2091235730 hasConceptScore W2091235730C2778750930 @default.
- W2091235730 hasConceptScore W2091235730C2778938600 @default.
- W2091235730 hasConceptScore W2091235730C2779166228 @default.
- W2091235730 hasConceptScore W2091235730C2779178603 @default.
- W2091235730 hasConceptScore W2091235730C2779886867 @default.
- W2091235730 hasConceptScore W2091235730C2781063702 @default.
- W2091235730 hasConceptScore W2091235730C55493867 @default.
- W2091235730 hasConceptScore W2091235730C75184817 @default.
- W2091235730 hasConceptScore W2091235730C86803240 @default.
- W2091235730 hasConceptScore W2091235730C95444343 @default.
- W2091235730 hasIssue "2" @default.
- W2091235730 hasLocation W20912357301 @default.
- W2091235730 hasLocation W20912357302 @default.
- W2091235730 hasOpenAccess W2091235730 @default.
- W2091235730 hasPrimaryLocation W20912357301 @default.
- W2091235730 hasRelatedWork W1869414709 @default.
- W2091235730 hasRelatedWork W1967208942 @default.
- W2091235730 hasRelatedWork W2010898616 @default.
- W2091235730 hasRelatedWork W2048712197 @default.
- W2091235730 hasRelatedWork W2052586191 @default.
- W2091235730 hasRelatedWork W2169658404 @default.
- W2091235730 hasRelatedWork W2315787918 @default.
- W2091235730 hasRelatedWork W2588482937 @default.
- W2091235730 hasRelatedWork W3138210248 @default.
- W2091235730 hasRelatedWork W4243372088 @default.
- W2091235730 hasVolume "415" @default.
- W2091235730 isParatext "false" @default.
- W2091235730 isRetracted "false" @default.
- W2091235730 magId "2091235730" @default.
- W2091235730 workType "article" @default.