Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091236224> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2091236224 endingPage "575" @default.
- W2091236224 startingPage "567" @default.
- W2091236224 abstract "An in vitro pharmacokinetic/pharmacodynamic perfusion model that simulates a two-compartment open model of serum drug concentration-time profiles following intravenous bolus injection and infusion was developed and mathematically described. In the present apparatus model, flow was kept in a one-way mode to avoid liquid traffic, and the washout effect seen in dilution models was overcome by embedding the tested bacteria in low melting point agarose gel. The validity of the equations and the reproducibility of the apparatus model were ascertained by simulating the concentration-time profiles of cefazolin and fosfomycin by substitution of their pharmacokinetic parameters obtained from humans for the equations. An empirical regimen 1X(q24h) of 1 g with cefazolin administered by intravenous infusion effectively killed a Staphylococcus aureus strain. The same regimen with fosfomycin produced a marked kill-curve with a fosfomycin-susceptible enterohaemorrhagic Escherichia coli O157:H7, whereas considerable regrowth was observed with a resistant strain. These results indicated that the present model was able to provide a convenient and reliable method for evaluating the efficacy of antimicrobial agents administered by intravenous infusion." @default.
- W2091236224 created "2016-06-24" @default.
- W2091236224 creator A5016381993 @default.
- W2091236224 creator A5029991223 @default.
- W2091236224 creator A5046828705 @default.
- W2091236224 creator A5084294149 @default.
- W2091236224 creator A5086996514 @default.
- W2091236224 creator A5088832721 @default.
- W2091236224 date "2007-05-01" @default.
- W2091236224 modified "2023-10-18" @default.
- W2091236224 title "A NovelIn VitroPharmacokinetic/Pharmacodynamic Model Based on Two-Compartment Open Model Used to Simulate Serum Drug Concentration-Time Profiles" @default.
- W2091236224 cites W1966400732 @default.
- W2091236224 cites W1991122147 @default.
- W2091236224 cites W1992515269 @default.
- W2091236224 cites W1997811421 @default.
- W2091236224 cites W2001811656 @default.
- W2091236224 cites W2020800366 @default.
- W2091236224 cites W2035143547 @default.
- W2091236224 cites W2070128858 @default.
- W2091236224 cites W2086564661 @default.
- W2091236224 cites W2096016476 @default.
- W2091236224 cites W2112056755 @default.
- W2091236224 cites W2112144297 @default.
- W2091236224 cites W2129419942 @default.
- W2091236224 cites W2137620161 @default.
- W2091236224 cites W2143264837 @default.
- W2091236224 cites W2155417557 @default.
- W2091236224 cites W2156783478 @default.
- W2091236224 cites W2334765105 @default.
- W2091236224 cites W4248036824 @default.
- W2091236224 doi "https://doi.org/10.1111/j.1348-0421.2007.tb03934.x" @default.
- W2091236224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17579267" @default.
- W2091236224 hasPublicationYear "2007" @default.
- W2091236224 type Work @default.
- W2091236224 sameAs 2091236224 @default.
- W2091236224 citedByCount "3" @default.
- W2091236224 countsByYear W20912362242022 @default.
- W2091236224 crossrefType "journal-article" @default.
- W2091236224 hasAuthorship W2091236224A5016381993 @default.
- W2091236224 hasAuthorship W2091236224A5029991223 @default.
- W2091236224 hasAuthorship W2091236224A5046828705 @default.
- W2091236224 hasAuthorship W2091236224A5084294149 @default.
- W2091236224 hasAuthorship W2091236224A5086996514 @default.
- W2091236224 hasAuthorship W2091236224A5088832721 @default.
- W2091236224 hasConcept C111113717 @default.
- W2091236224 hasConcept C112705442 @default.
- W2091236224 hasConcept C141071460 @default.
- W2091236224 hasConcept C2778353156 @default.
- W2091236224 hasConcept C2778897966 @default.
- W2091236224 hasConcept C2779489039 @default.
- W2091236224 hasConcept C2780035454 @default.
- W2091236224 hasConcept C2781413609 @default.
- W2091236224 hasConcept C501593827 @default.
- W2091236224 hasConcept C523546767 @default.
- W2091236224 hasConcept C54355233 @default.
- W2091236224 hasConcept C71924100 @default.
- W2091236224 hasConcept C86803240 @default.
- W2091236224 hasConcept C89423630 @default.
- W2091236224 hasConcept C98274493 @default.
- W2091236224 hasConceptScore W2091236224C111113717 @default.
- W2091236224 hasConceptScore W2091236224C112705442 @default.
- W2091236224 hasConceptScore W2091236224C141071460 @default.
- W2091236224 hasConceptScore W2091236224C2778353156 @default.
- W2091236224 hasConceptScore W2091236224C2778897966 @default.
- W2091236224 hasConceptScore W2091236224C2779489039 @default.
- W2091236224 hasConceptScore W2091236224C2780035454 @default.
- W2091236224 hasConceptScore W2091236224C2781413609 @default.
- W2091236224 hasConceptScore W2091236224C501593827 @default.
- W2091236224 hasConceptScore W2091236224C523546767 @default.
- W2091236224 hasConceptScore W2091236224C54355233 @default.
- W2091236224 hasConceptScore W2091236224C71924100 @default.
- W2091236224 hasConceptScore W2091236224C86803240 @default.
- W2091236224 hasConceptScore W2091236224C89423630 @default.
- W2091236224 hasConceptScore W2091236224C98274493 @default.
- W2091236224 hasIssue "5" @default.
- W2091236224 hasLocation W20912362241 @default.
- W2091236224 hasLocation W20912362242 @default.
- W2091236224 hasOpenAccess W2091236224 @default.
- W2091236224 hasPrimaryLocation W20912362241 @default.
- W2091236224 hasRelatedWork W1978032370 @default.
- W2091236224 hasRelatedWork W1979757582 @default.
- W2091236224 hasRelatedWork W1988935887 @default.
- W2091236224 hasRelatedWork W2090099591 @default.
- W2091236224 hasRelatedWork W2227061539 @default.
- W2091236224 hasRelatedWork W2332367370 @default.
- W2091236224 hasRelatedWork W2400461952 @default.
- W2091236224 hasRelatedWork W4285297479 @default.
- W2091236224 hasRelatedWork W79555446 @default.
- W2091236224 hasRelatedWork W2603979525 @default.
- W2091236224 hasVolume "51" @default.
- W2091236224 isParatext "false" @default.
- W2091236224 isRetracted "false" @default.
- W2091236224 magId "2091236224" @default.
- W2091236224 workType "article" @default.