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- W2091237014 abstract "Background:We tested recent evidences that IP triggers selective activation of protein kinase C (PKC isozymes using isolated Langendorff-perfused rabbit heart with PKC activator, phorbol ester (PMA, 0.01 nM or inhibitor (calphostin C, 200 nM. Methods:After stabilization of baseline hemodynamics, the hearts were subjected to 45 min global ischemia (Ⅰ followed by 120 min reperfusion (R with IP (IP group, n=18 or without IP (ischemic control group, n=16. IP was induced by single episode of 5 min Ⅰ and 10 min R. In the PMA-treated group (n=19 and calphostin C-treated preconditioned group (n=15, PMA and calphostin C was given for 5 and 15 min before 45 min Ⅰ, respectively. Myocardial cytosolic and membrane PKC activities were measured by 32P-γ-ATP incorporation into PKC-specific pepetide;PKC isozymes were analyzed by Western blot with monoclonal antibodies. Results:IP significantly increased the recovery of the LV function including LVDP and coronary flow (p<0.05; however, enhancement of the functional recovery disappeared by calphostin C or PMA treatment. Cytosolic PKC activity decreased to 82-76% in the IP and PMA-treated group (p<0.05; membrane PKC activity increased to 218-272% (p<0.01. However, both fraction of PKC activity was not changed in the calphostin C-treated preconditioned group. In addition, Western blot revealed that PKC-α and e, especially e, were selectively translocated during subsequent sustained ischemia after IP or PMA administration. IP and PMA also reduced infarct size (frim 38 to 10-20%, p<0.05. However, calphostin C blocked infarct reduction effect of IP. Conclusion:These results indicate that in isolated rabbit heart model, cardioprotective effect of IP may be related, at least in part, to trigger selective translocation of PKC, especially e isotype. (Korean Circulation J 1999;29(6 :602-611" @default.
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- W2091237014 date "1999-01-01" @default.
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- W2091237014 title "Cardioprotective Effect of the Ischemic Preconditioning: Its Relation to Activation of Protein Kinase C" @default.
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- W2091237014 doi "https://doi.org/10.4070/kcj.1999.29.6.602" @default.
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