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• W2091237142 endingPage "963" @default.
• W2091237142 startingPage "960" @default.
• W2091237142 abstract "Interleukin-18 (IL-18) binding protein is a soluble decoy receptor for IL-18 which efficiently antagonizes biological functions of IL-18 in vitro and in vivo. Since regulation of IL-18 activity likely contributes to the pathogenesis of inflammatory diseases as well as malignancies, we investigated gene expression of IL-18 binding protein (IL-18BP) in different human cell systems, namely in the keratinocyte cell line HaCaT, in the colon carcinoma cell line DLD-1, and in primary renal mesangial cells. In unstimulated cells only minute amounts of mRNA coding for IL-18 binding protein were detectable. However, in all three cell types gene expression was markedly upregulated by interferon-gamma (IFN-gamma). IL-18 is recognized as a pivotal mediator of IFN-gamma production. Therefore, the present data imply that activity of IL-18 is modulated by a negative feedback mechanism which is mediated by IFN-gamma-induced IL-18 binding protein." @default.
• W2091237142 created "2016-06-24" @default.
• W2091237142 creator A5002018691 @default.
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• W2091237142 date "2000-01-01" @default.
• W2091237142 modified "2023-09-24" @default.
• W2091237142 title "Interferon-γ Mediates Gene Expression of IL-18 Binding Protein in Nonleukocytic Cells" @default.
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• W2091237142 doi "https://doi.org/10.1006/bbrc.1999.2064" @default.
• W2091237142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10673399" @default.
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